{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T13:23:32Z","timestamp":1787405012726,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI 1185"],"award-info":[{"award-number":["KLI 1185"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI 854"],"award-info":[{"award-number":["KLI 854"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess optic nerve head blood flow (ONHBF) autoregulation in patients with early\u2010 to moderate\u2010stage primary open\u2010angle glaucoma (POAG) and age\u2010 and sex\u2010matched healthy controls using laser speckle flowgraphy (LSFG) and isometric handgrip exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010centre cross\u2010sectional study, 26 patients with early\u2010 to moderate\u2010stage POAG and 28 age\u2010 and sex\u2010matched healthy controls were included. ONHBF was measured using LSFG at baseline, during isometric handgrip exercise, and after recovery. Mean arterial pressure (MAP) was recorded at each measurement time point. The relative change in ONHBF during handgrip (\u0394BF) and a recovery index (RI) were calculated. Structural and vascular parameters including retinal nerve fibre layer thickness (RNFLT), retinal vessel diameters, and optical coherence tomography (OCT)\u2010angiography\u2010derived vessel density were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Glaucoma patients exhibited significantly lower RNFLT, ONHBF parameters, central retinal artery and vein equivalents, and selected vessel density parameters compared with controls (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). During isometric exercise, MAP increased similarly in both groups (glaucoma: +16\u2009\u00b1\u200911%; controls: +15\u2009\u00b1\u20098%; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 vs. baseline;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.981 between groups). However, ONHBF increased significantly more in glaucoma patients (23\u2009\u00b1\u200916%) than in controls (6\u2009\u00b1\u200913%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001, group\u2010by\u2010time interaction). The RI did not differ significantly between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.132).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with early\u2010 to moderate\u2010stage POAG exhibit an altered ONHBF response to isometric exercise despite a comparable increase in systemic blood pressure, suggesting impaired vascular autoregulatory capacity. LSFG combined with handgrip stimulation provides a feasible approach for assessing vascular regulation in glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      ID: NCT04596826.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70230","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:59:35Z","timestamp":1787403575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optic nerve head blood flow autoregulation during isometric exercise in primary open\u2010angle glaucoma assessed by laser speckle flowgraphy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3768-8585","authenticated-orcid":false,"given":"Theresa","family":"Lindner","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"},{"name":"VIROS \u2010 Vienna Institute for Research in Ocular Surgery \u2010 Karl Landsteiner Institute, Hanusch Hospital  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Janku","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Hommer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"},{"name":"VIROS \u2010 Vienna Institute for Research in Ocular Surgery \u2010 Karl Landsteiner Institute, Hanusch Hospital  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Hommer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"},{"name":"Hommer Ophthalmology Institute  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmyla","family":"Petric","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6935-9606","authenticated-orcid":false,"given":"Ulrich","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-1707","authenticated-orcid":false,"given":"Leopold","family":"Schmetterer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"},{"name":"Singapore Eye Research Institute, Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE), Nanyang Technological University  Singapore Singapore"},{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5547-5669","authenticated-orcid":false,"given":"Gerhard","family":"Garh\u00f6fer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-7768","authenticated-orcid":false,"given":"Doreen","family":"Schmidl","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2023.101217","article-title":"Neurovascular dysfunction in 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