{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:07:52Z","timestamp":1789456072291,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the association between accelerated biological ageing, measured by Phenotypic Age (PhenoAge) and PhenoAge Acceleration (PhenoAgeAccel), and features of early and intermediate age\u2010related macular degeneration (AMD) in a population\u2010based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study used data from the National Health and Nutrition Examination Survey. Biological age was estimated using the PhenoAge algorithm, a composite of routine blood biomarkers and chronological age, and PhenoAgeAccel was defined as the residual from regression of PhenoAge on chronological age. Retinal outcomes were drusen \u2265500\u2009\u03bcm (primary outcome), drusen \u2265125\u2009\u03bcm and pigmentary abnormalities. Associations were evaluated using logistic regression adjusted for biological sex, race\/ethnicity, smoking, body mass index and diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 5322 participants were included (mean age 59.4\u2009\u00b1\u200912.4\u2009years; 50.4% female). Drusen \u2265500\u2009\u03bcm were present in 4.1%, drusen \u2265125\u2009\u03bcm in 10.2% and pigmentary abnormalities in 5.6%. PhenoAgeAccel &gt;\u2009+\u20093\u2009years was associated with higher odds of drusen \u2265500\u2009\u03bcm (OR: 1.56, 95%CI: 1.07\u20132.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), whereas no association was observed for &lt;\u22123\u2009years. Each 1\u2010year increase in PhenoAgeAccel was associated with higher odds of drusen \u2265500\u2009\u03bcm (OR: 1.02, 95%CI: 1.00\u20131.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). PhenoAgeAccel &gt;\u2009+\u20093\u2009years was also associated with drusen \u2265125\u2009\u03bcm (OR: 1.29, 95%CI: 1.00\u20131.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), but not with pigmentary abnormalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Accelerated biological ageing was associated with increased drusen burden, but not pigmentary abnormalities, suggesting that early structural features of AMD may reflect broader systemic ageing processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70237","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:18:19Z","timestamp":1789453099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accelerated biological ageing is associated with a large drusen burden"],"prefix":"10.1111","author":[{"given":"Marie","family":"\u00d8rskov","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Ophthalmology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse J.","family":"Cehofski","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Ophthalmology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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Speciall\u00e6ger  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1699-7788","authenticated-orcid":false,"given":"Siar","family":"Niazi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"The E3 Lab University Hospital of Southern Denmark  S\u00f8nderborg Denmark"},{"name":"Steno Diabetes Center Copenhagen Copenhagen University Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne G.","family":"Schou","sequence":"additional","affiliation":[{"name":"The E3 Lab University Hospital of Southern Denmark  S\u00f8nderborg Denmark"},{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense 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