{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:42:11Z","timestamp":1792384931694,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010810","name":"\u00d6gonfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the repeatability of interpolated Pentacam HR elevation, densitometry and anterior chamber depth (ACD) map data before and after customized corneal crosslinking (CXL) in keratoconus (KC) and healthy eyes with low\u2010grade myopia (MY), including effects of KC severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants with progressive KC or stable MY treated with CXL were included from prospective studies. Eyes lacking complete 6\u2010 and 12\u2010month follow\u2010up or acceptable quality Pentacam HR examinations were excluded. Repeatability was assessed descriptively and using linear mixed\u2010effects models (LMMs) across groups and visits. KC severity analyses used baseline maximum keratometry (\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ), both continuously and categorically (KC high\/low).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010five right eyes (36 KC, 59 MY) were included. Variability was generally low and greater in KC only in central elevation (anterior,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; posterior,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; LMM). Nevertheless, model\u2010based limits for absolute differences between measurements, termed repeatability limits (RLs), did not exceed 1.66\u2009\u03bcm (maximum visit\u2010specific descriptive RL: 2.55\u2009\u03bcm). Descriptive comparisons indicated greater KC variability overall, mixed 6\u2010month changes and smaller group differences at 12\u2009months, but LMMs showed no significant post\u2010CXL repeatability changes. Selected parameters showed 4%\u20138% greater variability per 1\u2010D increase in\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      , and several elevation parameters and central ACD were more variable in KC high than KC low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interpolated Pentacam HR maps were highly repeatable, with no significant post\u2010CXL change. Variability appeared more strongly related to KC severity than diagnosis or visit. Subsequent derivation may contribute additional variability to conventional Pentacam parameters, particularly in more advanced KC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70245","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:35:01Z","timestamp":1792384501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repeatability of interpolated corneal tomography maps in healthy and keratoconus corneas before and after crosslinking"],"prefix":"10.1111","author":[{"given":"Anneli","family":"Fredriksson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences\/Ophthalmology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4899-7401","authenticated-orcid":false,"given":"Jad","family":"Hayek","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences\/Ophthalmology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Behndig","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences\/Ophthalmology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering10010039","article-title":"Limitations of reconstructing Pentacam rabbit corneal tomography by Zernike polynomials","volume":"10","author":"Baraya M.","year":"2022","journal-title":"Bioengineering"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y.","year":"1995","journal-title":"Journal of the Royal Statistical Society. 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