{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:31:01Z","timestamp":1778895061965,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Asthma is a heterogeneous and complex chronic inflammatory disease of the airways. Asthma can be classified as eosinophilic asthma (<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>) or noneosinophilic asthma (<jats:styled-content style=\"fixed-case\">NEA<\/jats:styled-content>). We investigated whether children with<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>manifest different clinical characteristics than those with<jats:styled-content style=\"fixed-case\">NEA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 288 steroid\u2010naive asthmatic children and classified them, based on the cell counts in induced sputum, into<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>(158 children) and<jats:styled-content style=\"fixed-case\">NEA<\/jats:styled-content>(89 children) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were observed between the groups with regard to age, sex, family history of atopy, secondary smoking or asthma exacerbations. Moderate\u2010to\u2010severe asthma was more frequent in the<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>group than in the<jats:styled-content style=\"fixed-case\">NEA<\/jats:styled-content>group. Blood eosinophil counts and serum eosinophil cationic protein were higher in<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>patients than in<jats:styled-content style=\"fixed-case\">NEA<\/jats:styled-content>patients. The forced expiratory volume in 1\u00a0sec was lower in children with<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>than in those with<jats:styled-content style=\"fixed-case\">NEA<\/jats:styled-content>(% of predicted value, 88.6\u00a0\u00b1\u00a018.5 vs. 93.6\u00a0\u00b1\u00a015.6, p\u00a0&lt;\u00a00.05). The sputum eosinophil (in<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>) and neutrophil (in<jats:styled-content style=\"fixed-case\">NEA<\/jats:styled-content>) counts increased with increasing asthma severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Airway inflammation, especially eosinophilic inflammation, was associated with asthma severity and reduced pulmonary function in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12046","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T06:31:42Z","timestamp":1351751502000},"page":"53-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical characteristics of eosinophilic and noneosinophilic asthma in children"],"prefix":"10.1111","volume":"102","author":[{"given":"Yong Ju","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kangnam Sacred Heart Hospital Hallym University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Institute of Allergy Severance Medical Research Institute Brain Korea 21 Project for Medical Sciences Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Good Gangan Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Hyun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Institute of Allergy Severance Medical Research Institute Brain Korea 21 Project for Medical Sciences Yonsei University College of Medicine Seoul 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