{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:22:48Z","timestamp":1775146968105,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T00:00:00Z","timestamp":1354838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Due to age\u2010dependent manifestations, diagnosis of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arfan syndrome (<jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>) in children and adolescents is sophisticated. Although revised Ghent criteria is a major step forward, its utility in children is still restricted due to expensive and technically advanced diagnostics. As early diagnosis submits long\u2010term benefits concerning prognosis, the need of an appropriate diagnostic tool for risk stratification of suspected paediatric patients with <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arfan is justified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sixty paediatric patients with <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arfan were subject to a standardized diagnostic programme. All clinical symptoms of the revised Ghent nosology were analysed concerning age at first clinical manifestation, prevalence and likelihood ratio for <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>. Symptoms with early onset, high prevalence and high positive likelihood ratio were identified and combined for a risk score called <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>id\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>hort <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arfan <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core (Kid\u2010<jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>). Three risk categories for suspicion of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arfan syndrome were developed. Finally, the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>id\u2010<jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content> was operated in 130 paediatric patients with suspected <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>. Kid\u2010<jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content> identified significantly more suspected patients with Marfan compared with <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>hent nosology, revised <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>hent and genetics alone without oversensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Whereas diagnosis of <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content> in childhood is sophisticated, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>id\u2010<jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content> is a useful tool for risk stratification of suspected paediatric patients with <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arfan by easy executable diagnostics, especially for paediatricians and paediatric cardiologists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12072","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T08:52:21Z","timestamp":1351587141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The <scp>K<\/scp>id\u2010<scp>S<\/scp>hort <scp>M<\/scp>arfan <scp>S<\/scp>core (<scp>K<\/scp>id\u2010<scp>SMS<\/scp>) \u2013 an easy executable risk score for suspected paediatric patients with <scp>M<\/scp>arfan syndrome"],"prefix":"10.1111","volume":"102","author":[{"given":"Goetz C","family":"Mueller","sequence":"first","affiliation":[{"name":"Clinic for Paediatric Cardiology University Heart Centre University of Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Stark","sequence":"additional","affiliation":[{"name":"Clinic for Paediatric Cardiology University Heart Centre University of 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