{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:36:11Z","timestamp":1780061771794,"version":"3.54.0"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T00:00:00Z","timestamp":1357257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>Aims<\/jats:title>To examine the relationship between early duct diameter and patent ductus arteriosus (PDA<\/jats:styled-content>) symptoms.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective study of infants <29\u00a0weeks of gestation with early colour Doppler assessment of PDA<\/jats:styled-content> diameter, in whom PDA<\/jats:styled-content> was managed conservatively, without cyclo\u2010oxygenase inhibitor (COI<\/jats:styled-content>) treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>Gestation and birthweight, [median (range)], were 26 (23\u201328) weeks and 865 (500\u20131440) g, respectively. Symptomatic PDA<\/jats:styled-content> developed in 20 (68.9%) infants, with 11 (37.9%) referred for PDA<\/jats:styled-content> ligation at 24 (17\u201330) days. Symptoms resolved spontaneously in 7 infants (24.1%) at 19 (7\u201332) days. There were 6 (20.7%) deaths, including four early neonatal deaths with large PDA<\/jats:styled-content>. Early colour Doppler PDA<\/jats:styled-content> diameter >1.5\u00a0mm (n\u00a0=\u00a020) predicted development of symptomatic PDA<\/jats:styled-content> (sensitivity 91%, specificity 100%), but symptoms resolved spontaneously without treatment in 30%. There was a significant linear correlation (p\u00a0<\u00a00.001) with increasing early PDA<\/jats:styled-content> diameter and the development of more persistent PDA<\/jats:styled-content> symptoms, early neonatal mortality and morbidity.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In our (COI<\/jats:styled-content>)\u2010na\u00efve population, the mortality and morbidity associated with prolonged exposure to unrestricted ducts are high. Not all infants with early PDA<\/jats:styled-content> diameter >1.5\u00a0mm have persistent symptomatic PDA<\/jats:styled-content>, but early PDA<\/jats:styled-content> diameter could be utilized to identify those infants at greatest risk of adverse outcome associated with PDA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12103","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T08:05:40Z","timestamp":1354003540000},"page":"254-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo\u2010oxygenase inhibitor na\u00efve population"],"prefix":"10.1111","volume":"102","author":[{"given":"Anne Marie","family":"Heuchan","sequence":"first","affiliation":[{"name":"Department of Neonatal Medicine The Royal Hospital for Sick Children Glasgow Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of Strathclyde Glasgow Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/fetalneonatal\u20102011\u2010301129"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70172-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.206052"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182084f8d"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.106569"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.75.3.F183"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.057638"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300381"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T08:08:13Z","timestamp":1700640493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,4]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/apa.12103"],"URL":"https:\/\/doi.org\/10.1111\/apa.12103","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,4]]},"assertion":[{"value":"2012-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}