{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:12:58Z","timestamp":1754111578730},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T00:00:00Z","timestamp":1357257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate whether coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) can be diagnosed by measuring autoantibodies without small\u2010intestinal mucosal biopsies in children with type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case finding of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> was undertaken in 181 consecutive <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2010competent children with type 1 diabetes using transglutaminase 2 (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2) and endomysial <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> antibody (<jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>) tests in serum and the rapid point of care test in fingertip whole\u2010blood sample. Endoscopy with intestinal biopsies was recommended for patients with high <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> titres (&gt;96\u00a0U) and in children with lower positive tests if either the <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> test or the rapid point of care test was additionally positive. The duodenal mucosal biopsies were graded according to the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arsh classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> test had a 15.5% and the <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> test a 6.0% seropositivity. All seven biopsied high\u2010titre <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2010positive children were symptom free and found to have <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arsh 3 type lesion). These patients were also positive for <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> and in the rapid point of care test. Lower titre <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2010positive children had histological <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arsh 1 to 3a lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>None of the type 1 diabetes children with high <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> titres would have needed endoscopy with duodenal biopsies to reach a <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> diagnosis. Lower <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2010positive patients need to be biopsied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12117","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T20:56:10Z","timestamp":1354654570000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prospective antibody case finding of coeliac disease in type\u20101 diabetes children: need of biopsy revisited"],"prefix":"10.1111","volume":"102","author":[{"given":"Alina","family":"Popp","sequence":"first","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest Romania"},{"name":"Paediatric Department Institute for Mother and Child Care \u201cAlfred Rusescu\u201d Bucharest Romania"},{"name":"Tampere Center for Child Health Research University of Tampere and Tampere University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Mihu","sequence":"additional","affiliation":[{"name":"Diabetes Department Emergency Hospital \u201cMarie Curie\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Diabetes Department Emergency Hospital \u201cMarie Curie\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina","family":"Ene","sequence":"additional","affiliation":[{"name":"Paediatric Department Institute for Mother and Child Care \u201cAlfred Rusescu\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Dutescu","sequence":"additional","affiliation":[{"name":"National Institute of Hematology and Blood Transfusion\u2010HLA Laboratory Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florin","family":"Colcer","sequence":"additional","affiliation":[{"name":"Paediatric Department Institute for Mother and Child Care \u201cAlfred Rusescu\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Raducanu","sequence":"additional","affiliation":[{"name":"Paediatric Department Institute for Mother and Child Care \u201cAlfred Rusescu\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaija","family":"Laurila","sequence":"additional","affiliation":[{"name":"Tampere Center for Child Health Research University of Tampere and Tampere University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Anca","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest Romania"},{"name":"Paediatric Department Institute for Mother and Child Care \u201cAlfred Rusescu\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Tampere Center for Child Health Research University of Tampere and Tampere University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283365263"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0797-797"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70008-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200011000-00013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.8.739"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0990"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200501000-00001"},{"key":"e_1_2_8_10_1","volume-title":"Type 1 diabetes: diagnosis and management of type 1 diabetes in children, young people and adults. 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