{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:46:41Z","timestamp":1777963601664,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The \u201013910C&gt;T single nucleotide polymorphism located upstream of the lactase gene (<jats:italic><jats:styled-content style=\"fixed-case\">LCT<\/jats:styled-content><\/jats:italic>) was found tightly associated with lactase persistence in European populations. Recently, it was also associated with body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and obesity in European adults. The aim of this study was to test the association of \u201013910C&gt;T polymorphism with obesity\u2010related traits and risk of obesity in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We genotyped 580 Portuguese children (6\u201312\u2010year\u2010olds) for the \u201013910C&gt;T polymorphism using TaqMan probes by real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Anthropometric measurements were assessed in all children. Obesity was defined according to the International Obesity Task Force (<jats:styled-content style=\"fixed-case\">IOTF<\/jats:styled-content>) cut\u2010offs and abdominal obesity using the sex and age\u2010specific \u226590th waist circumference percentile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found indication for an association between the\u201013910*T allele and children abdominal obesity (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]\u00a0=\u00a01.41; 95% confidence intervals [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 1.03\u20131.94; p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.030). Under the dominant model, the indicative association was observed between the <jats:italic><jats:styled-content style=\"fixed-case\">LCT<\/jats:styled-content><\/jats:italic>\u201013910 <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotypes and abdominal obesity, remaining significant after adjustment for age and gender (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.65; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.04\u20132.60; p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.029). No association was detected with the risk of obesity (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.350).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the \u201013910C&gt;T polymorphism may predispose to abdominal obesity in Portuguese children. The association with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> or risk of obesity, previously observed in adults, was not confirmed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12134","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T17:32:24Z","timestamp":1355851944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The lactase persistence \u201013910C&gt;T polymorphism shows indication of association with abdominal obesity among Portuguese children"],"prefix":"10.1111","volume":"102","author":[{"given":"David","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Department of Life Sciences Research Centre for Anthropology and Health (CIAS) University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9vio","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Center for Neurosciences &amp; Cell Biology (CNC) University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lic\u00ednio","family":"Manco","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Research Centre for Anthropology and Health (CIAS) University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp561"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.320"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043978"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.37.110801.143820"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409091740"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0593-6"},{"key":"e_1_2_10_8_1","first-page":"119","article-title":"Improving diagnosis of adult\u2010type hypolactasia in patients with abdominal complaints","volume":"50","author":"Haberkorn BC","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng826"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-10-36"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-005-1322-z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.8.821"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510015764"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1995.tb04456.x"},{"key":"e_1_2_10_16_1","first-page":"47","article-title":"Arlequin ver. 3.11: an integrated software package for population genetics data analysis. 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