{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:42:30Z","timestamp":1697445750234},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T00:00:00Z","timestamp":1358553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Chloral hydrate (<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>) is the most commonly used sedative for medical procedures and lung function tests in infancy. The aim was to determine whether moderate <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> sedation affects airway function, lung volume and ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen chronically instrumented 7\u2010 to 8\u2010week\u2010old lambs were studied both before and after <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> sedation (50\u00a0mg\/kg as intravenous bolus followed by 25\u00a0mg\/kg\/hour as continuous infusion). Nitrogen washout technique and lung mechanics analysis were used to assess functional residual capacity (<jats:styled-content style=\"fixed-case\">FRC<\/jats:styled-content>) and airway function. Moment analysis and lung clearance index were calculated as measures of gas mixing efficiency in distal airways. Respiratory rate, tidal volume, minute ventilation and indices of inspiratory drive were determined together with heart rate, blood pressure and oxygenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>\u2010induced changes were found for gas mixing efficiency, <jats:styled-content style=\"fixed-case\">FRC<\/jats:styled-content> or lung mechanics. Minute ventilation decreased slightly, but significantly, while indices of inspiratory drive remained unchanged. Heart rate increased significantly, but mean arterial blood pressure was unaffected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Moderate <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> sedation did not significantly affect airway function or <jats:styled-content style=\"fixed-case\">FRC<\/jats:styled-content>. Although indices of inspiratory drive were not affected, minute ventilation decreased slightly. These findings indicate that reliable results can be obtained from lung function testing when <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> is used for sedation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12151","type":"journal-article","created":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T17:58:30Z","timestamp":1357322310000},"page":"391-396","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardio\u2010respiratory response to moderate chloral hydrate sedation in young lambs"],"prefix":"10.1111","volume":"102","author":[{"given":"Kenneth L.","family":"Sandberg","sequence":"first","affiliation":[{"name":"Department of Paediatrics Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley D.","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan W.","family":"Sundell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283423e6b"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1542\/peds.92.3.471","article-title":"Use of Chlorohydrate for sedation in children","volume":"92","author":"American Academy of Pediatrics Committee on Drugs and Committee on Environmental Health","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_9_4_1","unstructured":"The National Institute for Heath and Clinical Excellence (NICE).Sedation in children and young people (CG112): Sedation for diagnostic and therapeutic procedures in children and young people 2010. 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