{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:07:23Z","timestamp":1791058043225,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether absent or reversed end\u2010diastolic flow in the umbilical artery (<jats:styled-content style=\"fixed-case\">AREDF<\/jats:styled-content>) is associated with neonatal mortality, morbidity or long\u2010term neurocognitive outcome in extremely preterm infants exposed to preeclampsia or intrauterine growth restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prenatal Doppler data were retrospectively collected for liveborn infants with gestational age (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) &lt;28\u00a0weeks or birth weight (<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>) &lt;1000\u00a0g, born small for gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>\u2010 <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> &lt;5th percentile for <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) or of mothers with preeclampsia at the four largest university hospitals in Norway during 1999\u20132000. Neonatal mortality and morbidities, cerebral palsy (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content> at 5\u00a0years of age were compared for infants with or without <jats:styled-content style=\"fixed-case\">AREDF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 260 infants, 84 were eligible and 71 of them had sufficient Doppler data. Of these, 38 (54%) had <jats:styled-content style=\"fixed-case\">AREDF<\/jats:styled-content>. Of 33 infants born &lt;28\u00a0weeks, 7 of 19 (37%) with <jats:styled-content style=\"fixed-case\">AREDF<\/jats:styled-content> and none of 14 without <jats:styled-content style=\"fixed-case\">AREDF<\/jats:styled-content> had severe cerebral haemorrhage (<jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>) (p\u00a0=\u00a00.01). <jats:styled-content style=\"fixed-case\">AREDF<\/jats:styled-content> was not significantly associated with mortality, other <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> morbidities, <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> or reduced <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content>. For the 38 infants with <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> \u226528\u00a0weeks, <jats:styled-content style=\"fixed-case\">AREDF<\/jats:styled-content> (19 of 38) was not associated with adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Absent or reversed end\u2010diastolic flow in the umbilical artery (<jats:styled-content style=\"fixed-case\">AREDF<\/jats:styled-content>) was associated with increased risk of <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content> in extremely preterm infants (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> &lt;28\u00a0weeks).<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12164","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T03:15:11Z","timestamp":1358478911000},"page":"403-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Foetal 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