{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:21:27Z","timestamp":1778905287619,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To determine the true prevalence of congenital heart disease (CHD<\/jats:styled-content>) at live birth using echocardiographic screening.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 5190 consecutive newborns from two secondary hospitals were included. Each neonate had a complete clinical evaluation with echocardiographic diagnosis at average 47\u00a0h of age. Newborns with persistent CHD<\/jats:styled-content> underwent at least 4\u00a0months of follow\u2010up, and the temporal trend of prevalence of mild CHD<\/jats:styled-content> was assessed.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall live birth prevalence of CHD<\/jats:styled-content> was 26.6\u2030 (severe 3.5\u2030, moderate 5.4\u2030 and mild 17.7\u2030), and prevalence of CHD<\/jats:styled-content> that could be detected by clinical evaluation was 12.1\u2030. The most common CHD<\/jats:styled-content> was ventricular septal defect (VSD<\/jats:styled-content>, 17.3\u2030), followed by atrial septal defect (ASD<\/jats:styled-content>, 6.2\u2030), patent ductus arteriosus (PDA<\/jats:styled-content>, 1.3\u2030), tetralogy of Fallot (TOF<\/jats:styled-content>, 0.4\u2030), single ventricle (SV<\/jats:styled-content>, 0.4\u2030), atrioventricular septal defect (AVSD<\/jats:styled-content>, 0.2\u2030) and double outlet right ventricle (DORV<\/jats:styled-content>, 0.2\u2030). Female predominance was observed in mild CHD<\/jats:styled-content> (VSD<\/jats:styled-content>, ASD<\/jats:styled-content>), and male predominance was observed in severe CHD<\/jats:styled-content>. The prevalence of CHD<\/jats:styled-content> was reduced to 19.5\u2030 at the 4\u2010month follow\u2010up, which was largely caused by spontaneous closure rate of muscular VSD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Prevalence of CHD<\/jats:styled-content> determined by echocardiography screening was higher but more accurate than that obtained from birth defect registries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12170","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T14:05:02Z","timestamp":1359122702000},"page":"397-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Prevalence of congenital heart disease at live birth: an accurate assessment by echocardiographic screening"],"prefix":"10.1111","volume":"102","author":[{"given":"Qu\u2010ming","family":"Zhao","sequence":"first","affiliation":[{"name":"Pediatric Heart Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010jing","family":"Ma","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Jia","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center Children's Hospital of Fudan University Shanghai 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