{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:38:06Z","timestamp":1790289486621,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To estimate the transmission of maternal vaginal microbiota to neonates during term delivery, focusing on <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>actobacillus<\/jats:italic> flora in relation to various obstetric clinical factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty consecutive pregnant healthy women with singleton term pregnancies and their newborn infants. Vertical transmission of <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>actobacillus<\/jats:italic> flora to the newborn during delivery was evaluated in 45 mother\u2013newborn pairs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>actobacillus<\/jats:italic>\u2010dominant mixed flora was detected in 90% (N\u00a0=\u00a045) of vaginal samples, but only in 28% (N\u00a0=\u00a014) of neonatal cultures (transmission rate 31%). All neonates with <jats:italic>Lactobacillus<\/jats:italic>\u2010dominant mixed flora had findings similar to those in maternal cultures. Cocci\u2010dominant flora was the most common finding in neonates. Administration of antibiotics to the mother during the intrapartum period before birth and duration of rupture of membranes (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>), regardless of maternal antibiotic treatment, were associated significantly with a decreased transmission rate of <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>actobacillus<\/jats:italic>\u2010dominant mixed flora to neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal intrapartum antibiotics and prolonged expectant management after <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> were associated with decreased transmission rate of vaginal <jats:italic>Lactobacillus<\/jats:italic> flora to the neonate during birth. As early colonization of <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>actobacillus<\/jats:italic> flora may have a preventive role in the development of allergic diseases later, the significance of intrapartum prophylactic antibiotics needs to be highlighted in forthcoming studies, especially as regards immunological development of the offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12186","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T13:20:07Z","timestamp":1360243207000},"page":"480-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Maternal intrapartum antibiotics and decreased vertical transmission of <i><scp>L<\/scp>actobacillus<\/i> to neonates during birth"],"prefix":"10.1111","volume":"102","author":[{"given":"Leea","family":"Keski\u2010Nisula","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Kuopio University Hospital Kuopio Finland"},{"name":"Department of Environmental Health National Institute for Health and Welfare Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna\u2010Reetta","family":"Kyyn\u00e4r\u00e4inen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"K\u00e4rkk\u00e4inen","sequence":"additional","affiliation":[{"name":"Eastern Finland Laboratory Centre Joint Authority Enterprise Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Karhukorpi","sequence":"additional","affiliation":[{"name":"Eastern Finland Laboratory Centre Joint Authority Enterprise Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Heinonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Pekkanen","sequence":"additional","affiliation":[{"name":"Department of Environmental Health National Institute for Health and Welfare Kuopio Finland"},{"name":"School of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2824"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.9.1796S"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2009.00553.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199901000-00007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/523336"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000191137.12774.b2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900802339734"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03156.x"},{"key":"e_1_2_9_11_1","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease\u2010revised guidelines from CDC, 2010","volume":"59","author":"Verani JR","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_9_12_1","first-page":"CD007482","article-title":"Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section","volume":"1","author":"Smaill FM","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00323-08"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.2.297-301.1991"},{"key":"e_1_2_9_15_1","first-page":"CD008726","article-title":"Different classes of antibiotics given to women routinely for preventing infection at caesarean section","volume":"10","author":"Alfirevic Z","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.03.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181d1b11e"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91845-2"},{"key":"e_1_2_9_19_1","first-page":"543","article-title":"Microbial invasion of the amniotic cavity during term labor. 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