{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:08:01Z","timestamp":1759410481433},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the incidence and characteristics of blood culture\u2010positive occult pneumococcemia compared with blood culture\u2010positive pneumococcal pneumonia in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In years 2001\u20132010, 105 children with positive blood cultures for <jats:italic>Streptococcus\u00a0pneumoniae<\/jats:italic> were identified from hospital electronic files. The patient cards were retrospectively charted for clinical and laboratory data, and 38 patients had and 67 had not pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The annual incidence of pneumococcemia was, on average, 29.0\/10\u00a0000 at 0\u201312\u00a0months, 5.3\/10\u00a0000 at 13\u201324\u00a0months and 1.9\/10\u00a0000 at 2\u20134\u00a0years of ages, with no increasing or decreasing trend. The incidence of bacteraemic pneumococcal pneumonia increased (p\u00a0=\u00a00.022) during the study period. The duration of fever before hospitalization (&lt;24\u00a0h 73.9% vs. 25.0%, p\u00a0=\u00a00.022) and the duration of intravenous antibiotics, usually G\u2010penicillin (median 72 vs. 96\u00a0h, p\u00a0=\u00a00.021) was shorter in pneumococcemia patients. On admission, blood leucocyte count was higher in pneumococcemia (mean 26.6 vs. 21.9\u00a0\u00d7\u00a010E9\/L, p\u00a0=\u00a00.012), but serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was higher in pneumonia (median 160 vs. 67.4\u00a0mg\/L, p\u00a0&lt;\u00a00.001). The serotypes 6B and 14 caused 53.2% of pneumococcemia cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of pneumococcemia was highest in 1\u20132\u2010year\u2010old children, and typical for pneumococcemia was rapid onset of fever, high blood leucocyte count and a modestly elevated <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> on admission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12194","type":"journal-article","created":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T16:14:39Z","timestamp":1360426479000},"page":"514-519","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pneumococcemia in children \u2013 a retrospective study before universal pneumococcal vaccinations"],"prefix":"10.1111","volume":"102","author":[{"given":"Henna","family":"Karppa","sequence":"first","affiliation":[{"name":"Paediatric Research Centre Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risto","family":"Vuento","sequence":"additional","affiliation":[{"name":"Fimlab Laboratories Pirkanmaa Hospital District Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maija","family":"Toropainen","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Helsinki and Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarja","family":"Kaijalainen","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Helsinki and Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotta","family":"Siira","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Helsinki and Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[{"name":"Paediatric Research Centre Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2002.01124.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05182-11"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-004-1197-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.83.3.231"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e23"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200111000-00005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199811000-00004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb00137.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2006.10.026"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.7.671"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.156.9.905"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200107000-00004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540801938931"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181eaf89a"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e32831cefc9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181dbd820"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.10.012"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01841.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2002.11007801.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000066242.21072.9d"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01924.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2003.1111005.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.10.006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01748.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pec.0000215137.51909.16"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02648.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.58879"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490230053027"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T08:27:58Z","timestamp":1700641678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,28]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/apa.12194"],"URL":"https:\/\/doi.org\/10.1111\/apa.12194","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,28]]},"assertion":[{"value":"2012-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}