{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:12:32Z","timestamp":1791936752122,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Toll\u2010like receptors are vital transmembrane receptors that initiate the innate immune response to many micro\u2010organisms. The discovery of these receptors has improved our understanding of host\u2013pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll\u2010like receptors, especially <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Toll\u2010like receptor modulation may potentially be used as immunomodulators in the management of neonatal sepsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12201","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T17:13:33Z","timestamp":1361294013000},"page":"572-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Toll\u2010like receptors in <scp>N<\/scp>eonatal <scp>S<\/scp>epsis"],"prefix":"10.1111","volume":"102","author":[{"given":"Fiona M","family":"O\u2019Hare","sequence":"first","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"William Watson","sequence":"additional","affiliation":[{"name":"School of Medicine &amp; Medical Science University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor J","family":"Molloy","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"},{"name":"School of Medicine &amp; Medical Science University College Dublin Dublin Ireland"},{"name":"Department of Paediatrics Royal College of Surgeons of Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.04.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.7.4286"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/704202"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199901000-00001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.03.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211317"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2005.05.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.155"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602007000200001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010111"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/344893"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200209000-00011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.5.3171"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21248"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.132"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.11.6398-6401.2000"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000069343.27691.F3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.6141"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04350.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198609000-00019"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000180544.02537.FD"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181f90810"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091743"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v30i2.979"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1223-1229.2004"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.11.011"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/509892"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6324"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6449"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3059"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.481292"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.05.003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308057100"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200104000-00023"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182093280"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200101000-00018"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.1.134"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181647b3a"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200701-051OC"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.7.3920"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2431"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819f195d"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02552.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00131.2010"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.7.3934"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513041200"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807268200"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909361107"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/08828240260066279"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.002"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1086\/367990"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b07b78"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.019695"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.06.027"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181e7c5c9"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.06.013"},{"key":"e_1_2_10_59_1","first-page":"825","article-title":"Ketamine suppresses intestinal TLR4 expression and NF\u2010kappaB activity in lipopolysaccharide\u2010treated rats","volume":"47","author":"Yu M","year":"2006","journal-title":"Croat Med J"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12201","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:18:24Z","timestamp":1697613504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,6]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/apa.12201"],"URL":"https:\/\/doi.org\/10.1111\/apa.12201","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,6]]},"assertion":[{"value":"2012-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}