{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:33:14Z","timestamp":1793493194798,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Both hypothermia and central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) drugs may alter the predictive accuracy of amplitude\u2010integrated electroencephalography (a<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) in hypoxic\u2013ischaemic encephalopathy (<jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>). The aim was to assess the predictive value of a<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> in hypothermia\u2010treated <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> infants. Furthermore, we intended to investigate the association of cumulative doses of <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> drugs with a<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy term <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> infants treated with hypothermia for 72\u00a0h were continuously monitored by single\u2010channel a<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>. Doses of administered morphine, phenobarbitone and midazolam were recorded. Poor outcome was defined as death or severe neurodevelopmental delay at 18\u201024\u00a0months (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ayley <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cales of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nfant <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>evelopment II), good outcome as absence of these criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Poor outcome n\u00a0=\u00a026, good outcome n\u00a0=\u00a044. Positive predictive values (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>) of an abnormal background pattern to predict poor outcome were 0.5 at 6\u00a0h; 0.65 at 24\u00a0h; 0.82 at 48\u00a0h and 0.92 at 60\u00a0h. All infants who developed sleep\u2013wake cycling (<jats:styled-content style=\"fixed-case\">SWC<\/jats:styled-content>) had a favourable outcome; the nondevelopment of <jats:styled-content style=\"fixed-case\">SWC<\/jats:styled-content> resulted in a <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> of 0.73 for a poor outcome. Cumulative doses of the investigated drugs did not differ between infants having an onset of a recovered background pattern before or after 24\u00a0h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Amplitude\u2010integrated electroencephalography provides reliable prediction of outcome from the 48th hour during hypothermia in <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> infants. Commonly used <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> drugs in <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> infants do not significantly delay a<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> recovery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12226","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T08:10:47Z","timestamp":1366099847000},"page":"707-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Accuracy of amplitude\u2010integrated electroencephalography in the prediction of neurodevelopmental outcome in asphyxiated infants receiving hypothermia treatment"],"prefix":"10.1111","volume":"102","author":[{"given":"AJ","family":"Csek\u0151","sequence":"first","affiliation":[{"name":"1st Department of Paediatrics Semmelweis University Budapest 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