{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:46:30Z","timestamp":1769510790500,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Evaluation of the prevalence of coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) in Greek paediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The project consists of two parts: (i) a pilot study of preschool children aged 2\u20136\u00a0years to test the feasibility and diagnostic accuracy of community\u2010based screening and (ii) a CD prevalence study, by random clustered sampling and proportionate stratification of various geographical areas in Greece. Trained nonmedical staff performed a rapid immunochromatographic test to detect IgA antibodies to <jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content>\u2010IgA and IgA deficiency. Toddlers with positive results were referred to a paediatric gastroenterologist for further assessment with serum anti\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> IgA and EMA\u2010IgA. Children with positive serum anti\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> and anti\u2010EMA underwent upper gastrointestinal tract endoscopy and small bowel biopsy and were subsequently in gluten\u2010free diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this project participated 1136 toddlers, who were tested at school. The prevalence of positive rapid anti\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> screening was 1:154, of IgA deficiency 1:120 and of biopsy\u2010proven CD 1:154. The prevalence of CD from this pilot study served as expected prevalence value for sample size calculation for the main prevalence study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This protocol using rapid immunochromatographic test for the detection of both IgA deficiency and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> is easy to be performed by nonmedical staff in a community setting, enabling the accurate identification of new <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> cases among asymptomatic population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12241","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T08:56:43Z","timestamp":1366621003000},"page":"749-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Screening for coeliac disease in preschool Greek children: the feasibility study of a community\u2010based project"],"prefix":"10.1111","volume":"102","author":[{"given":"Thomai","family":"Karagiozoglou\u2010Lampoudi","sequence":"first","affiliation":[{"name":"\u201cChristos Mantzoros\u201d Clinical Nutrition Lab Nutrition and Dietetics Department, School of Food Technology and Nutrition Technological Education Institute Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aglaia","family":"Zellos","sequence":"additional","affiliation":[{"name":"1st Department of Pediatrics \u201cAghia Sophia\u201d Children's Hospital School of Medicine University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Vlahavas","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetics Department School of Food Technology and Nutrition Technological Education Institute Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yota","family":"Kafritsa","sequence":"additional","affiliation":[{"name":"\u201cEuroclinic\u201d Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftheria","family":"Roma","sequence":"additional","affiliation":[{"name":"1st Department of Pediatrics \u201cAghia Sophia\u201d Children's Hospital School of Medicine University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"\u201cAglaia Kyriakou\u201d Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Fotoulaki","sequence":"additional","affiliation":[{"name":"Fourth Pediatric Department \u201cPapageorgiou\u201d Hospital Aristotle University of Thessaloniki Nea Efkarpia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavroula","family":"Karyda","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cG. 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