{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:55:56Z","timestamp":1769637356101,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the efficacy and tolerance of betamethasone (<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>) and hydrocortisone (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) in weaning extremely low birth weight (<jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content>) infants with bronchopulmonary dysplasia (<jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>) from the ventilator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Monocentric, retrospective, cohort analysis based on prospective, standardized collection of data between 2005 and 2011 in <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> receiving postnatal steroids (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) after the second week of life. We used <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> for the first 4\u00a0years, and thereafter <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. We compared extubation rates, growth, glycaemia and blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven infants received <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>: 35 <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> and 32 <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. Most infants (83% <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> vs. 72% <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) were extubated during treatment (p\u00a0=\u00a00.281). During <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>, the need for insulin was similar. Mean arterial blood pressure was similar at day 3 of <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>, but was significantly lower in infants treated by <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> 30\u00a0days after the end of treatment. The z\u2010scores for body weight and head circumference indicated significantly greater loss in <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> group. This persisted only for body weight after adjustment for differences in energy intake and corticosteroid dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> may be as efficient as <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> in facilitating the extubation of <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants, without short\u2010term adverse effects. Blood pressure monitoring and investigation of long\u2010term neurodevelopment are nevertheless needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12255","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T19:07:59Z","timestamp":1365016079000},"page":"689-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Postnatal steroids in extremely low birth weight infants: betamethasone or hydrocortisone?"],"prefix":"10.1111","volume":"102","author":[{"given":"Mohamed","family":"Ben Said","sequence":"first","affiliation":[{"name":"Neonatology University Hospital Croix Rousse Hospices Civils de Lyon Lyon France"},{"name":"Faculty of Medicine of Tunis University of Tunis El\u2010Manar Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Hays","sequence":"additional","affiliation":[{"name":"Neonatology University Hospital Croix Rousse Hospices 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