{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T19:51:25Z","timestamp":1772740285667,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Recent research suggests that asthma may originate through defects in the airway epithelium, acquired <jats:italic>in utero<\/jats:italic>, and an altered response to infections after birth. Here, we examine whether asthma in adult life is associated with reduced body size at birth and poor living conditions in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 658 people taking medication for asthma in a cohort of 13\u00a0345 men and women born in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elsinki, <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>inland, during 1934\u20131944. Their body and placental size at birth, and their living conditions and growth in childhood, had been recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The odds ratios for asthma were 0.93 (95% CI 0.89\u20130.97, p\u00a0=\u00a00.001) per cm increase in birth length and 0.92 (0.89\u20130.96, p\u00a0&lt;\u00a00.001) per cm increase in the length of placental surface. After allowing for size at birth, growth during childhood was unrelated to asthma. People who were born into families of low socio\u2010economic status were at increased risk of later asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Slow linear growth <jats:italic>in utero<\/jats:italic>, which could be a result of impaired placentation, increases the risk of later asthma. Slow linear growth may be associated with impaired development of the airways. Babies with impaired lung development born into families of low socio\u2010economic status may be most vulnerable to the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12257","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T11:16:47Z","timestamp":1365419807000},"page":"732-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Foetal and childhood growth and asthma in adult life"],"prefix":"10.1111","volume":"102","author":[{"given":"David JP","family":"Barker","sequence":"first","affiliation":[{"name":"Heart Research Center Oregon Health and Science University Portland OR USA"},{"name":"MRC Lifecourse Epidemiology Unit Southampton General Hospital University of Southampton Southampton UK"},{"name":"Chair of Fetal Programming King Saud University Riyadh Saudi 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Finland"},{"name":"Hospital for Children and Adolescents Helsinki University Central Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan G","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Health Care University of Helsinki Helsinki Finland"},{"name":"Department of Chronic Disease Prevention National Institute for Health and Welfare Helsinki Finland"},{"name":"Folkh\u00e4lsan Research Centre Helsinki Finland"},{"name":"Unit of General Practice Helsinki University Central Hospital Helsinki Finland"},{"name":"Vasa Central Hospital Vasa Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090474"},{"key":"e_1_2_7_3_1","first-page":"439","article-title":"A new look at the pathogenesis of asthma: the 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