{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:00:26Z","timestamp":1791154826520,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Although the body length and weight of an infant are related to head circumference, little research on ASDs has examined these factors. Our study compared the head circumferences of neonates who were later diagnosed with ASD with a control group. Additional comparisons on morphological disproportions at birth included the head circumference\u2010to\u2010height and head circumference\u2010to\u2010weight ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 422 children with ASD and 153 typically developing children. Head circumference, body length and weight at birth were collected and standardized as percentile scores according to gestational age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results revealed that genuine macrocephaly was significantly higher in children with other pervasive developmental disorders compared with the control group. This difference was not observed with regard to genuine microcephaly. Relative macrocephaly and relative microcephaly were significantly more frequent in children with autism disorder compared with the control group with regard to body length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The differences in relative macrocephaly and microcephaly, as well as in other parameters, between diagnostic subgroups suggest that the presence of several neurological mechanisms plays a role in the later expression of different phenotypes. An increased head circumference\u2010to\u2010body length ratio in newborns may be a factor to follow that could be related to ASD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12264","type":"journal-article","created":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T12:54:42Z","timestamp":1365857682000},"page":"901-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Autism spectrum disorders: head circumference and body length at birth are both relative"],"prefix":"10.1111","volume":"102","author":[{"given":"Marine","family":"Grandgeorge","sequence":"first","affiliation":[{"name":"Centre de Ressources Autisme CHRU de Brest H\u00f4pital de Bohars Bohars France"},{"name":"Laboratory of Neurosciences de Brest, EA 4685 University of Bretagne Occidentale Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lemonnier","sequence":"additional","affiliation":[{"name":"Centre de Ressources Autisme CHRU de Brest H\u00f4pital de Bohars Bohars France"},{"name":"Laboratory of Neurosciences de Brest, EA 4685 University of Bretagne Occidentale Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelle","family":"Jallot","sequence":"additional","affiliation":[{"name":"Centre de Ressources Autisme CHRU de Brest H\u00f4pital de Bohars Bohars France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp261"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361306066601"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3113"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36735"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.026"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023036509476"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.3.337"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31465"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001211)95:4<339::AID-AJMG9>3.0.CO;2-B"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199702000-00019"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.245"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2011.02238.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-007-0405-1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.09.014"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807304005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2002.tb00814.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1019-6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537727"},{"key":"e_1_2_12_20_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_12_21_1","volume-title":"Diagnostic Criteria for Research","author":"World Health Organisation","year":"1994"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172145"},{"key":"e_1_2_12_23_1","volume-title":"Auxologie M\u00e9thode et S\u00e9quences","author":"Semp\u00e9 M","year":"1979"},{"key":"e_1_2_12_24_1","volume-title":"Multiple Congenital Anomaly Syndromes: A Catalogue of Human Malformation Syndromes \u2010 First Supplement","author":"Winter RM","year":"1993"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.08.005"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)62956-X"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2009.07.001"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1266"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80623-8"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi123"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1606"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12264","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:48:34Z","timestamp":1696495714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,28]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/apa.12264"],"URL":"https:\/\/doi.org\/10.1111\/apa.12264","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,28]]},"assertion":[{"value":"2013-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}