{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:03:16Z","timestamp":1767826996816,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Mami Mizutani foundation"},{"name":"Human Resource Chair"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Haemodynamically significant patent ductus arteriosus (hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>) is frequently observed in premature infants. This study was conducted to explore whether the blood <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> can be a valuable biomarker to assess the necessity of treatment for hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> in premature infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serial measurements of the blood <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> were performed during the first 5\u00a0days of life in premature infants with hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> (Group I) and those without hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> (Group N). The definition of the hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> was the <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> requiring treatment, such as indomethacin administration and\/or surgical ligation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six subjects were enrolled. Compared with Group N, Group I showed significantly higher level of blood <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> at postnatal 24\u201396\u00a0h and demonstrated the peak value at postnatal 24\u201348\u00a0h. With the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve using the data at postnatal 24\u201348\u00a0h in Group I, we deduced the predictive value of 250\u00a0pg\/mL of blood <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> for indomethacin treatment. Similarly, with the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve using the maximal value of blood <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> within the first 5\u00a0days of life, the predictive value of 2000\u00a0pg\/mL for surgical ligation was deduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Blood <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> during early postnatal period can be a useful biomarker to assess the necessity of treatment for hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> in premature infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12273","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T07:47:33Z","timestamp":1366789653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["B\u2010type natriuretic peptide for assessment of 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