{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:03:18Z","timestamp":1788469398209,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Indications for post\u2010natal steroids among preterm infants are evolving. The objective of this study was to compare steroid use in 2 cohorts 5\u00a0years apart and to document the short\u2010 and long\u2010term outcomes of our most recent cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review of infants born under 28\u00a0weeks of gestational age for two cohorts (<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2002\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2003 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2008\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and fourteen infants were included. More infants received steroids in the later cohort (20% vs 35%, p\u00a0=\u00a00.021) but survival rates did not improve. There was a shift towards hydrocortisone use (&lt;7% vs 76%) and pulmonary indications (36% vs 61% of courses; p\u00a0=\u00a00.021). Patients died later (8\u00a0days vs 30\u00a0days; p\u00a0=\u00a00.02), with a strong correlation between time of death and total dose of steroids (r\u00a0=\u00a00.91; p\u00a0=\u00a00.01). Neurodevelopmental outcomes for patients who received steroids for pulmonary indications were inferior to those for the rest of the cohort (severe adverse outcome 26% vs 4.8%, p\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The improvement in short\u2010term respiratory status of ill preterm patients was offset by a disturbing increase in age at death and no improvement in survival rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12285","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T10:08:42Z","timestamp":1367834922000},"page":"799-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evolving neonatal steroid prescription habits and patient outcomes"],"prefix":"10.1111","volume":"102","author":[{"given":"\u00c9tienne","family":"Fortin\u2010Pellerin","sequence":"first","affiliation":[{"name":"Neonatology division Department of Pediatrics Centre Hospitalier Universitaire de Sherbrooke Sherbrooke University Sherbrooke QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Neonatology division Department of Pediatrics University of Montreal Sainte\u2010Justine Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith J","family":"Barrington","sequence":"additional","affiliation":[{"name":"Neonatology division Department of Pediatrics University of Montreal Sainte\u2010Justine Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Janvier","sequence":"additional","affiliation":[{"name":"Neonatology division Department of Pediatrics University of Montreal Sainte\u2010Justine Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-1-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.1.15"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.83.3.F177"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.330"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1272"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2793"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.126"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2806"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008\u20101928."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0796"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1991.tb01906.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1238"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2011.12.017"},{"key":"e_1_2_8_15_1","first-page":"897","article-title":"Controlled trial of dexamethasone in neonatal chronic lung disease: a 3\u2010year follow\u2010up","volume":"96","author":"Jones R","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb02512.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200301000-00014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200106000-00011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.5.1223"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00247.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.06.046"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2843"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.187203"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12285","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12285","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:06:30Z","timestamp":1696496790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,15]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/apa.12285"],"URL":"https:\/\/doi.org\/10.1111\/apa.12285","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,15]]},"assertion":[{"value":"2012-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}