{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:10:40Z","timestamp":1764259840527},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the different characteristics of girls with pituitary hyperplasia secondary to primary hypothyroidism (<jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content>), with and without sexual precocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pituitary hyperplasia secondary to primary hypothyroidism girls were divided into two groups: group A, with sexual precocity (n\u00a0=\u00a08), and group B, without sexual precocity (n\u00a0=\u00a014). The following values were measured before and after 3\u00a0months levothyroxine therapy: free triiodothyronine (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content><jats:sub>3<\/jats:sub>), free thyroxine (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content><jats:sub>4<\/jats:sub>), thyrotropin (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>), follicle\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>), luteinising hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>), prolactin (<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>), estradiol (E<jats:sub>2<\/jats:sub>), testosterone (T), pituitary height, uterine volume (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>), ovarian volume (<jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>) and follicular diameter (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thyrotropin, <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PRL<\/jats:styled-content>, E<jats:sub>2<\/jats:sub>, T, pituitary height, <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> were higher in group A than group B (all p\u00a0&lt;\u00a00.05); <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content><jats:sub>3<\/jats:sub>, <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content><jats:sub>4<\/jats:sub> and <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> levels were not different (all p\u00a0&gt;\u00a00.05). In all of the <jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content> girls, pituitary height was correlated with <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content><jats:sub>3<\/jats:sub>, <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content><jats:sub>4<\/jats:sub> and <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> (r\u00a0=\u00a0\u22120.545, p\u00a0=\u00a00.009, r\u00a0=\u00a0\u22120.567, p\u00a0=\u00a00.006 and r\u00a0=\u00a00.666, p\u00a0=\u00a00.001, respectively). <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> was positively correlated with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> (r\u00a0=\u00a00.581, p\u00a0=\u00a00.005, r\u00a0=\u00a00.482, p\u00a0=\u00a00.031 and r\u00a0=\u00a00.667, p\u00a0=\u00a00.001, respectively), and <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> was positively correlated with <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> (r\u00a0=\u00a00.522, p\u00a0=\u00a00.013). These abnormalities regressed after therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pituitary hyperplasia secondary to primary hypothyroidism girls with sexual precocity have increased plasma <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FSH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PRL<\/jats:styled-content>, E<jats:sub>2<\/jats:sub> and T levels, pituitary height and uterine, ovarian and follicular size.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12444","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:41:51Z","timestamp":1381545711000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characteristics of girls with pituitary hyperplasia and sexual precocity secondary to primary 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