{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:05:41Z","timestamp":1768986341241,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the feasibility of discontinuing thyroid hormone treatment earlier than recommended by the current guidelines for congenital hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of very low\u2010birthweight (<jats:styled-content style=\"fixed-case\">VLBW<\/jats:styled-content>) infants born at <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hungbuk <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital from <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2006 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2010. Infants were divided into two groups \u2013 hypothyroid and normal thyroid \u2013 on the basis of the thyroid function test results. Infants in the hypothyroid group were treated with levothyroxine (<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>4) and attempts to discontinue this therapy began when they were about 2\u00a0years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 216 infants born during the study period, 20 died and 196 were included in the study. Of these, 46 were in the hypothyroid group and 150 were in the normal thyroid group. Thirty\u2010nine infants were taken off <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>4 therapy at around 2\u00a0years of age. All were successfully weaned off <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>4 and retained normal thyroid function. <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>c\u201099\u00a0m thyroid scans were performed in 32 infants, and no distinct abnormality was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thyroid dysfunction in <jats:styled-content style=\"fixed-case\">VLBW<\/jats:styled-content> infants was common in our cohort and most cases were transient. Attempts to discontinue this therapy could begin at around the age of two or earlier when low doses of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>4 have achieved maintenance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12450","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:03:56Z","timestamp":1381543436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Early discontinuation of thyroxine therapy is possible in most very low\u2010birthweight infants with hypothyroidism detected by screening"],"prefix":"10.1111","volume":"103","author":[{"given":"Gina","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ulsan University Hospital University of Ulsan College of Medicine Ulsan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungbuk National University Hospital Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heon\u2010Seok","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungbuk National University Hospital Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1975F"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.09.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440601123446"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2010.23.1-2.45"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0915"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-10-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_10_10_1","first-page":"317","article-title":"Thyroid function and dysfunction in premature infants","volume":"4","author":"Fisher DA","year":"2007","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02536.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.4.627"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2011.02033.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9286-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0632"},{"key":"e_1_2_10_16_1","first-page":"331","article-title":"Serial blood T4 and TSH determinations in low birth weight infants. 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