{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:15:01Z","timestamp":1781842501205,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of oral sucrose combined with non\u2010nutritive sucking for reducing pain associated with retinopathy of prematurity screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomised controlled study of 64 infants undergoing eye examination for retinopathy of prematurity screening. Topical anaesthetic (Proparacaine; Alcaine<jats:sup>\u00ae<\/jats:sup> drop 0.5%: ALCON CANADA Inc., Mississauga, Canada) was applied 30\u00a0sec before the eye examination in all infants. The infants in intervention group (Group 1, n\u00a0=\u00a032) received 0.5\u00a0mL\/kg of 24% sucrose with a pacifier. The control group (Group 2, n\u00a0=\u00a032) received 0.5\u00a0mL\/kg of sterile water with a pacifier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The groups had similar gestational ages (28.5\u00a0\u00b1\u00a02.8\u00a0weeks), mean birthweight (1304\u00a0\u00b1\u00a0466\u00a0g) or corrected gestational age (35.4\u00a0\u00b1\u00a03.7\u00a0weeks) at examination. The intervention group had a significantly lower mean Premature Infant Pain Profile score during examination of the first eye, following insertion of the speculum (Group 1:13.7\u00a0\u00b1\u00a02.1 vs. Group 2:16.4\u00a0\u00b1\u00a01.8, p<jats:italic>\u00a0=<\/jats:italic>\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although sucrose combined with non\u2010nutritive sucking modestly reduces pain scores during eye examinations, there is need to further studies to explore significant pain relief for infants undergoing retinopathy of prematurity screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12454","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T09:38:37Z","timestamp":1384162717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Oral sucrose and non\u2010nutritive sucking goes some way to reducing pain during retinopathy of prematurity eye examinations"],"prefix":"10.1111","volume":"103","author":[{"given":"Dilek","family":"Dilli","sequence":"first","affiliation":[{"name":"Department of Neonatology Dr Sami Ulus Maternity and Children Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisa Eda \u00c7ullas","family":"\u0130larslan","sequence":"additional","affiliation":[{"name":"Department of Neonatology Dr Sami Ulus Maternity and Children Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah Utku","family":"Kabata\u015f","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Dr Sami Ulus Maternity and Children Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015feg\u00fcl","family":"Zenciro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neonatology Dr Sami Ulus Maternity and Children Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u0131ld\u0131z","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Neonatology Dr Sami Ulus Maternity and Children Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurullah","family":"Okumu\u015f","sequence":"additional","affiliation":[{"name":"Department of Neonatology Dr Sami Ulus Maternity and Children Training and Research Hospital Ankara 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