{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:39:33Z","timestamp":1791110373866,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To find out whether there was an association between when complementary feeding was introduced and the appearance of atopic eczema in children with a family history of allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study followed 256 mother and child pairs until the child was four\u2010years\u2010old. Repeated skin prick testing was performed and a clinical diagnosis of eczema made by a physician. The mothers kept a continuous diary about the introduction of complementary feeding. To control the possible reverse causation of delaying complementary food introduction due to presumed child allergy, parental suspicions of allergic reactions were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The introduction of cereals and fish after seven\u2010months\u2010of\u2010age was associated with an increased risk of atopic eczema. However, when the parents' suspicions that their child might be exhibiting symptoms of allergic disease were taken into account, this effect was no longer significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found no evidence that the timing of the introduction of complementary feeding increased the risk of atopic eczema in a high\u2010risk cohort, when parental suspicions were taken into account. Therefore, it seems that families with a history of allergy can safely comply with current feeding recommendations, although confirmation in further studies is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12458","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:39:49Z","timestamp":1381545589000},"page":"168-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Timing of complementary feeding and the risk of atopic eczema"],"prefix":"10.1111","volume":"103","author":[{"given":"Katri","family":"Niinivirta","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences University of Turku Turku Finland"},{"name":"Department of Paediatrics Turku University Hospital Turku Finland"},{"name":"Functional Foods Forum University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Isolauri","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences University of Turku Turku Finland"},{"name":"Department of Paediatrics Turku University Hospital Turku Finland"},{"name":"Functional Foods Forum University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja","family":"Nermes","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences University of Turku Turku Finland"},{"name":"Department of Paediatrics Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Functional Foods Forum University of Turku Turku Finland"},{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0271-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2011.00363.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000304464.60788.bd"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2903\/j.efsa.2009.1423","article-title":"Scientific opinion on the appropriate age for introduction of complementary feeding of infants","volume":"7","author":"European Food Safety Authority (EFSA), EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)","year":"2009","journal-title":"EFSA Journal"},{"key":"e_1_2_10_7_1","unstructured":"World Health Organization (WHO).Report of the expert consultation of the optimal duration of exclusive breastfeeding.Geneva Switzerland:World Health Organization 2001."},{"key":"e_1_2_10_8_1","unstructured":"Scientific Advisory Committee on Nutrition (SACN) Subgroup on Maternal and Child Nutrition (SMCN).Paper for discussion: introduction of solid foods agenda item: 3. SMCN\/03\/08 2003."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61364-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2005.07.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1996.tb00407.x"},{"key":"e_1_2_10_12_1","first-page":"63","article-title":"The concept of oral tolerance induction to foods","volume":"59","author":"Lack G","year":"2007","journal-title":"Nestle Nutr Workshop Ser Pediatr Program"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1542\/peds.2006-3553","article-title":"Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6\u00a0years: results from the prospective birth cohort study LISA","volume":"121","author":"Zutavern A","year":"2008","journal-title":"Pediatrics"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.36.2.118"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1651"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.028"},{"issue":"1203","key":"e_1_2_10_18_1","first-page":"e1205","article-title":"Early complementary feeding and risk of food sensitization in a birth cohort","volume":"127","author":"Joseph CL","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.1999.00022.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.117067"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.048"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)38153-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02696.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.001180"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1803"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6892.1572"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70074-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.160.5.502"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.028"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2382"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12458","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:39:18Z","timestamp":1696484358000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/apa.12458"],"URL":"https:\/\/doi.org\/10.1111\/apa.12458","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,3]]},"assertion":[{"value":"2013-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}