{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:56:40Z","timestamp":1754110600819},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Patients with inflammatory bowel disease (IBD<\/jats:styled-content>) are prone to cardiovascular disorders, although there is little research to support this assertion, and other data are controversial in children. We aimed to determine the extent of premature atherosclerosis in Crohn's disease (CD<\/jats:styled-content>) by measuring reactive hyperaemia index (RHI<\/jats:styled-content>) as a functional marker of endothelial dysfunction (ED<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010one patients with CD<\/jats:styled-content> and twelve healthy matched subjects were enrolled in the study. Diagnosis was based on the standard clinical, endoscopic and histological criteria, including the Paediatric Crohn's disease Activity Index. ED<\/jats:styled-content> was assessed using the plethysmographic RHI<\/jats:styled-content>, combined with specific biochemical markers of ED<\/jats:styled-content>.<\/jats:p><\/jats:sec>Result<\/jats:title>RHI<\/jats:styled-content> values were significantly lower in the patients with CD<\/jats:styled-content> than the controls (p\u00a0<\u00a00.05). E\u2010selectin (p\u00a0<\u00a00.05), asymmetric dimethylarginine (p\u00a0<\u00a00.01) and high\u2010sensitive CRP<\/jats:styled-content> (p\u00a0<\u00a00.05), but not vascular cells adhesive molecule\u20101 values, were significantly increased in the CD<\/jats:styled-content> subjects compared with the control group.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Significantly decreased RHI<\/jats:styled-content> and elevated plasma levels of specific biochemical parameters seems to be related to systemic inflammation and ED<\/jats:styled-content> in children with CD<\/jats:styled-content>. Our results support the hypothesis regarding RHI<\/jats:styled-content> and ED<\/jats:styled-content> in paediatric CD<\/jats:styled-content>. This combined method assessment might be a useful tool for detection of ED<\/jats:styled-content> and stratification of cardiovascular risk in patients with CD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12467","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T16:47:33Z","timestamp":1381855653000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reactive hyperaemia index as a marker of endothelial dysfunction in children with C<\/scp>rohn's disease is significantly lower than healthy controls"],"prefix":"10.1111","volume":"103","author":[{"given":"Jehlicka","family":"Petr","sequence":"first","affiliation":[{"name":"Department of Paediatrics Faculty Hospital Pilsen Czech Republic"},{"name":"Faculty of Medicine in Pilsen Charles University in Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huml","family":"Michal","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Faculty Hospital Pilsen Czech Republic"},{"name":"Faculty of Medicine in Pilsen Charles University in Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schwarz","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Faculty Hospital Pilsen Czech Republic"},{"name":"Faculty of Medicine in Pilsen Charles University in Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trefil","family":"Ladislav","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Heamatology Faculty Hospital Pilsen Czech Republic"},{"name":"Faculty of Medicine in Pilsen Charles University in Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kobr","family":"Jiri","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Faculty Hospital Pilsen Czech Republic"},{"name":"Faculty of Medicine in Pilsen Charles University in Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sykora","family":"Josef","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Faculty Hospital Pilsen Czech Republic"},{"name":"Faculty of Medicine in Pilsen Charles University in Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21171"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i5.578"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467210801030195"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2000.2288"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2148-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00247.2005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.748574"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.07.034"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.08.062"},{"key":"e_1_2_10_11_1","first-page":"413","article-title":"Value of E\u2010selectin and L\u2010selectin determination in children and youth with inflammatory bowel disease","volume":"11","author":"Adamska I","year":"2007","journal-title":"Med Wieku Rozwoj"},{"key":"e_1_2_10_12_1","first-page":"77","article-title":"In situ expression of the cell adhesion molecules in inflammatory bowel disease. Evidence of immunologic activation of vascular endothelial cells","volume":"69","author":"Nakamura S","year":"1993","journal-title":"Lab Invest"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20994"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.03.043"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000163736.30261.82"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199105000-00005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100229"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.05.013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0646-y"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31819d8489"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319710387918"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1042404"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-333"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.33549\/physiolres.931418","article-title":"Asymmetric dimethylarginine and the effect of folate substitution in children with familial hypercholesterolemia and diabetes mellitus type 1","volume":"58","author":"Jehlicka P","year":"2009","journal-title":"Physiol Res"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X12436708"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S2769"},{"key":"e_1_2_10_28_1","first-page":"904141","article-title":"Evaluation of the EndoPAT as a Tool to Assess Endothelial Function","volume":"2012","author":"Moerland M","year":"2012","journal-title":"Int J Vasc Med"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01086.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1235-0"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.152777"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12467","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:38:58Z","timestamp":1696484338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,13]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/apa.12467"],"URL":"https:\/\/doi.org\/10.1111\/apa.12467","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,13]]},"assertion":[{"value":"2013-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}