{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:22:14Z","timestamp":1773285734469,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Whole body hypothermia (<jats:styled-content style=\"fixed-case\">WBH<\/jats:styled-content>) exerts proven neuroprotective effects in infants with hypoxic\u2010ischaemic encephalopathy (<jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>). Our aim was to describe how <jats:styled-content style=\"fixed-case\">WBH<\/jats:styled-content> could impact on respiratory function in mechanically ventilated newborn infants, by recording primary and composite indices of oxygenation and ventilation before, during and after <jats:styled-content style=\"fixed-case\">WBH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical notes of 31 mechanically ventilated full\u2010term newborn infants who underwent <jats:styled-content style=\"fixed-case\">WBH<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> were retrospectively reviewed. Fraction of inspired oxygen (FiO<jats:sub>2<\/jats:sub>), tidal volume (<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>), mean airway Pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>), minute ventilation (<jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content>), static compliance of the respiratory system (C<jats:sub>stat<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:sub>RS<\/jats:sub><\/jats:styled-content>), ventilation efficiency index (<jats:styled-content style=\"fixed-case\">VEI<\/jats:styled-content>), alveolar\u2010arterial gradient (A\u2010a gradient) and oxygenation index (<jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content>) were documented before and during hypothermic treatment, as well as during and after rewarming.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fraction of inspired oxygen, <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OI<\/jats:styled-content> and A\u2010a gradient decreased during induction of hypothermia and tended to increase during rewarming. C<jats:sub>stat<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:sub>RS<\/jats:sub><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VEI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> increased during induction of hypothermia and tended to decrease during rewarming. None of the changes achieved statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that <jats:styled-content style=\"fixed-case\">WBH<\/jats:styled-content> might affect respiratory function in mechanically ventilated infants with <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>. Oxygenation might be enhanced by hypothermia, probably as a result of decreased metabolism, while ventilation might also be facilitated as a result of the effect of hypothermia on lung mechanics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12476","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T07:01:06Z","timestamp":1382425266000},"page":"157-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Respiratory function parameters in ventilated newborn infants undergoing whole body hypothermia"],"prefix":"10.1111","volume":"103","author":[{"given":"Theodore","family":"Dassios","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit Rosie Maternity Hospital Cambridge University Hospitals NHS Foundation Trust Hills Road Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Topun","family":"Austin","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Rosie Maternity Hospital Cambridge University Hospitals NHS Foundation Trust Hills Road Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"1","author":"Jacobs SE","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199710200-00033"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.25.1.105"},{"key":"e_1_2_6_5_1","volume-title":"Guyton and Hall Textbook of Medical Physiology","author":"Hall J","year":"2011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181aa5241"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/79.6.726"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.146977"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1542\/peds.67.4.474","article-title":"Effects of alterations of inspiratory and expiratory pressures and inspiratory\/expiratory ratios on mean airway pressure, blood gases, and intracranial pressure","volume":"67","author":"Stewart AR","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.70.1.F11"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.12.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1103154"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008506-199707000-00001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-197809000-00011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197907000-00007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.09.006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.181826"},{"key":"e_1_2_6_18_1","first-page":"107","article-title":"Cardiovascular and respiratory status in mechanically ventilated asphyxiated term infants: comparison between hypothermic and control group","volume":"75","author":"Lista G","year":"2004","journal-title":"Acta Biomed"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12476","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:39:30Z","timestamp":1696484370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,20]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/apa.12476"],"URL":"https:\/\/doi.org\/10.1111\/apa.12476","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,20]]},"assertion":[{"value":"2013-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}