{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:44:08Z","timestamp":1767923048026,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Preterm children are at risk of developing increased blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>). We evaluated possible associations between <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, early insulin\u2010like growth factor\u20101 (<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101) and <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010binding protein\u20101 (<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101) levels and retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>) in preterm children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 32 infants: median gestational age 28.1\u00a0weeks (range 24.6<jats:bold>\u2013<\/jats:bold>31.3) and birthweight standard deviation scores (<jats:styled-content style=\"fixed-case\">SDS<\/jats:styled-content>) (\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) 1.0\u00a0\u00b1\u00a02.7. <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 at postnatal weeks 32.6\u201334.6 and <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> stages were established after birth. <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was measured at the age of 4\u00a0years. The ratio (<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101)<jats:sup>2<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 was created to investigate the influence of both <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 to later <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> correlated with <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101, inversely correlated with <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101<jats:sup>2<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 (r\u00a0=\u00a0\u22120.71, p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and positively correlated with catch\u2010up growth velocity from lowest weight <jats:styled-content style=\"fixed-case\">SDS<\/jats:styled-content> to age 36.5\u00a0weeks (r<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.48, p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01), independent of gestational age. Children with moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> as neonates had higher mean arterial <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> [78 (\u00b195%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 74\u201383) vs 71 (\u00b195%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 68\u201375) mm Hg, p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05] adjusted for gestational age and birthweight <jats:styled-content style=\"fixed-case\">SDS<\/jats:styled-content> compared to children diagnosed with no to mild <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low neonatal <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101<jats:sup>2<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 and severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> were associated with higher <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in 4\u2010year\u2010old children born very preterm and may thus predict future cardiovascular morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12478","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T07:01:11Z","timestamp":1382425271000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neonatal <scp>IGF<\/scp>\u20101\/<scp>IGFBP<\/scp>\u20101 axis and retinopathy of prematurity are associated with increased blood pressure in preterm children"],"prefix":"10.1111","volume":"103","author":[{"given":"Anna","family":"Kistner","sequence":"first","affiliation":[{"name":"The Sahlgrenska Center for Pediatric Ophthalmology Research Institute of Neuroscience and Physiology Gothenburg 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