{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:57:16Z","timestamp":1761400636174},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health","award":["ROI HD 057098"],"award-info":[{"award-number":["ROI HD 057098"]}]},{"name":"Doris Duke Foundation"},{"name":"Washington University Intellectual and Developmental Disabilities Research Center","award":["NIH\/NICHD P30 HD062171"],"award-info":[{"award-number":["NIH\/NICHD P30 HD062171"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><\/jats:sec><jats:sec><jats:label \/><jats:p>To determine the associations between perinatal exposures, cerebral maturation on amplitude\u2010integrated encephalography (<jats:styled-content style=\"fixed-case\">aEEG<\/jats:styled-content>) and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During this prospective cohort study, 136 infants \u226430\u00a0weeks estimated gestational age received 4\u00a0h of <jats:styled-content style=\"fixed-case\">aEEG<\/jats:styled-content> at four time points (between the first 2\u00a0weeks of life and term\u2010equivalent age) during hospitalisation. Perinatal factors were documented. Associations between perinatal exposures and Burdjalov\u2010scores were investigated. Neurodevelopmental outcome was assessed at the age of two.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immature cyclicity on the initial <jats:styled-content style=\"fixed-case\">aEEG<\/jats:styled-content> recording was associated with higher CRIB score (p\u00a0=\u00a00.01), vaginal delivery (p\u00a0=\u00a00.02), male gender (p\u00a0&lt;\u00a00.01) and death (p\u00a0=\u00a00.01). Perinatal factors associated with lower <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>urdjalov\u2010scores included cerebral injury (p\u00a0&lt;\u00a00.01), sepsis (p\u00a0&lt;\u00a00.01), lower caffeine dose (p\u00a0=\u00a00.006), prolonged mechanical ventilation (p\u00a0=\u00a00.002) and death (p\u00a0&lt;\u00a00.01). Burdjalov\u2010scores at 30 (<jats:italic>\u03b2\u00a0<\/jats:italic>=\u00a02.62, p\u00a0&lt;\u00a00.01) and 34\u00a0weeks postmenstrual age (<jats:italic>\u03b2\u00a0<\/jats:italic>=\u00a02.89, p\u00a0=\u00a00.05) predicted motor scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">aEEG<\/jats:styled-content> measures of cyclicity and Burdjalov\u2010scores in the first 6\u00a0weeks of life, with an emphasis on 30 and 34\u00a0weeks postmenstrual age, demonstrated associations with perinatal factors known to predict adverse neurodevelopmental outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12485","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T19:19:48Z","timestamp":1382728788000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cerebral maturation on amplitude\u2010integrated electroencephalography and perinatal exposures in preterm infants"],"prefix":"10.1111","volume":"103","author":[{"given":"Lauren C","family":"Reynolds","sequence":"first","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta G","family":"Pineda","sequence":"additional","affiliation":[{"name":"Program in Occupational Therapy Washington University School of Medicine St. Louis MO USA"},{"name":"Department of Pediatrics Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudine","family":"Vavasseur","sequence":"additional","affiliation":[{"name":"Department of Newborn Medicine National Maternity Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyen K","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neonatology Barts and the London Childrens Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrie","family":"Inder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University School of Medicine St. Louis MO USA"},{"name":"Department of Neurology Washington University School of Medicine St. Louis MO USA"},{"name":"Department of Radiology Washington University School of Medicine St. Louis MO 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