{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:15:05Z","timestamp":1785500105918,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000861","name":"Sparks","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the aetiological associations, neurological sequelae and role of magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) in term newborn infants with seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cohort study of infants \u226537\u00a0weeks' gestation delivered in a tertiary level centre, prospectively identified and followed longitudinally for 18\u201324\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An underlying aetiology was found in 95% of the 77 infants identified with seizures (3.0\/1000 live births). The most common diagnosis was hypoxic\u2013ischaemic encephalopathy (<jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>) (65%), followed by neonatal stroke (12%). Nine infants died, 28 of the 68 survivors developed neurodevelopmental impairment (<jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>), and 15 had recurrent seizures in the first 2\u00a0years, with both outcomes more likely in those with a diagnosis other than <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>. Abnormal <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> findings were found in 45 of the 70 infants imaged. The absence of major cerebral lesions was highly predictive of a normal neurological outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report the first cohort of term infants with seizures fully investigated by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. The universal use of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> enabled a cause to be identified in 95% of cases. The probability of having <jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content> or recurrence of seizures was extremely low with absence of major cerebral lesions on <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. This study demonstrates the added value of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> for diagnosis of aetiology and the prediction of neurological outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12583","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T16:28:47Z","timestamp":1391531327000},"page":"820-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neonatal seizures: magnetic resonance imaging adds value in the diagnosis and prediction of neurodisability"],"prefix":"10.1111","volume":"103","author":[{"given":"Elizabeth","family":"Osmond","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care unit St Michael's Hospital Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiel","family":"Billetop","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care unit St Michael's Hospital Bristol 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