{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:18:17Z","timestamp":1788196697426,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Neonatal abstinence syndrome (<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>) is a drug withdrawal syndrome, secondary to <jats:italic>in utero<\/jats:italic> chemical exposure and characterised by tremor, irritability and feed intolerance. It often requires prolonged hospital treatment and separation of families. Outpatient therapy may reduce this burden, but current literature is sparse. This review aimed to evaluate the safety and efficacy of our home\u2010based detoxification programme and compare it with standard inpatient care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants requiring treatment for <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> between January 2004 and December 2010 were reviewed. Data on demographics, drug exposure, length of stay and type of therapy were compared between infants selected for home\u2010based therapy and those treated conventionally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 118 infants who were admitted for treatment of <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>, 38 (32%) were managed at home. Infants receiving home\u2010based detoxification had shorter hospital stays (mean 19\u00a0days vs. 39\u00a0days), with no increase in total duration of treatment (mean 36\u00a0days vs. 41\u00a0days), and were more likely to be breastfeeding on discharge from hospital care (45% vs. 22%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In selected infants, home\u2010based detoxification is associated with reduced hospital stays and increased rates of breastfeeding, without prolonging therapy. Safety of the infants remains paramount, which precludes many from entering such a programme.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12603","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T12:13:23Z","timestamp":1392725603000},"page":"601-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Home\u2010based detoxification for neonatal abstinence syndrome reduces length of hospital admission without prolonging treatment"],"prefix":"10.1111","volume":"103","author":[{"given":"Cameron L.","family":"Smirk","sequence":"first","affiliation":[{"name":"Department of Newborn Services Royal Women's Hospital Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Bowman","sequence":"additional","affiliation":[{"name":"Women's Alcohol and Drug Service Royal Women's Hospital Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lex W.","family":"Doyle","sequence":"additional","affiliation":[{"name":"Newborn Research Royal Women's Hospital Parkville VIC Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Kamlin","sequence":"additional","affiliation":[{"name":"Department of Newborn Services Royal Women's Hospital Parkville VIC Australia"},{"name":"Newborn Research Royal Women's Hospital Parkville VIC Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.152769"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211427"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2000.00492.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/935631"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2001.00657.x"},{"key":"e_1_2_7_8_1","first-page":"19","article-title":"Assessment and treatment of abstinence in the infant of the drug\u2010dependent mother","volume":"12","author":"Finnegan L","year":"1975","journal-title":"Int J Clin Pharmacol Biopharm."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2007.01.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.3951"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2888"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1561"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-0994-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.00994.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005359"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2003.00551.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0978"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:13:01Z","timestamp":1696515181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,18]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/apa.12603"],"URL":"https:\/\/doi.org\/10.1111\/apa.12603","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,18]]},"assertion":[{"value":"2013-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}