{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:47:05Z","timestamp":1777340825157,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine the relevance of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>7\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2 typing in a prospective cohort of paediatric coeliac disease patients from Southern Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study tested 249 paediatric patients with coeliac disease. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2 was typed in combination with <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>7\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2 to screen for the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2 haplotype. The histological, analytical and clinical characteristics of the subjects were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 91 coeliac patients were diagnosed: 96.7% carried <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2 and 4.4% carried <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>8. In percentage terms, 80.2% of patients carried <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2 and 34.1% carried <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>7\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2. We did not find significant differences between HLA\u2010DR7\u2010DQ2 and HLA\u2010DR3\u2010DQ2 paediatric patients with respect to histological damage and clinical characteristics, except for irritability and weight loss. These characteristics were more frequent in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2<jats:sub>trans<\/jats:sub> than in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2<jats:sub>cis<\/jats:sub> (22.2% vs. 0.0% [p\u00a0=\u00a00.035] and 55.6% vs. 21.4% [p\u00a0=\u00a00.017], respectively). Coeliac\u2010specific autoantibody levels were higher in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2<jats:sub>cis<\/jats:sub> than one half of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2<jats:sub>trans<\/jats:sub> patients (105.5 vs. 19.2\u00a0U\/m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>, p\u00a0=\u00a00.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Small clinical differences were found between paediatric coeliac patients carrying <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>7\u2010DQ2 and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2. For a correct screening of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2, at least in our geographical population, the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>7\u2010<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2 haplotype should be typed due to its frequency and clinical presentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12605","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T12:49:05Z","timestamp":1392900545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Paediatric celiac patients carrying the <scp>HLA<\/scp>\u2010<scp>DR<\/scp>7\u2010<scp>DQ<\/scp>2 and <scp>HLA<\/scp>\u2010<scp>DR<\/scp>3\u2010<scp>DQ<\/scp>2 haplotypes display small clinical differences"],"prefix":"10.1111","volume":"103","author":[{"given":"Juan F.","family":"Delgado","sequence":"first","affiliation":[{"name":"Immunology Section Laboratory UDIAT\u2010Centre Diagn\u00f2stic Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed Sabadell Spain"},{"name":"Institut Universitari Parc Taul\u00ed\u2010UAB Universitat Aut\u00f2noma de Barcelona Campus d'Excel\u00e8ncia Internacional Bellaterra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda J.","family":"Amengual","sequence":"additional","affiliation":[{"name":"Immunology Section Laboratory UDIAT\u2010Centre Diagn\u00f2stic Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed Sabadell Spain"},{"name":"Institut Universitari Parc Taul\u00ed\u2010UAB Universitat Aut\u00f2noma de Barcelona Campus d'Excel\u00e8ncia Internacional Bellaterra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Veraguas","sequence":"additional","affiliation":[{"name":"Immunology 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