{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:10:54Z","timestamp":1787062254056,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,15]],"date-time":"2014-03-15T00:00:00Z","timestamp":1394841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Preterm infants requiring surfactant replacement have been treated using the\n                      <jats:styled-content style=\"fixed-case\">INSURE<\/jats:styled-content>\n                      technique, which requires sedation and comprises tracheal intubation, surfactant instillation and extubation. However, minimally invasive surfactant therapy (\n                      <jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>\n                      ) does not require sedation, minimises airway injury and avoids placing positive pressure ventilation on an immature lung. This study compared the feasibility of the two techniques and the outcomes in preterm babies with respiratory distress syndrome (\n                      <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Preterm infants with\n                      <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>\n                      prospectively received surfactant via a gastric tube placed in the trachea by direct laryngoscopy with no sedation. Technique\u2010related complications and respiratory outcomes were analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We compared 44 patients who received\n                      <jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>\n                      with a historic cohort of 31 patients who received\n                      <jats:styled-content style=\"fixed-case\">INSURE<\/jats:styled-content>\n                      . This showed no differences in the rate of intubation and mechanical ventilation in the first 72\u00a0h, or secondary respiratory outcomes and relevant morbidities, between the babies who received\n                      <jats:styled-content style=\"fixed-case\">INSURE<\/jats:styled-content>\n                      and those who received\n                      <jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>\n                      . More babies in the\n                      <jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>\n                      group (35%) needed a second dose of surfactant than the\n                      <jats:styled-content style=\"fixed-case\">INSURE<\/jats:styled-content>\n                      group (6.5%) (p\u00a0&lt;\u00a00.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Surfactant administration using\n                      <jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>\n                      , with no sedation, is feasible in preterm infants with\n                      <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>\n                      . No significant differences in secondary respiratory outcomes were found between the\n                      <jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">INSURE<\/jats:styled-content>\n                      techniques.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.12611","type":"journal-article","created":{"date-parts":[[2014,3,15]],"date-time":"2014-03-15T04:21:06Z","timestamp":1394857266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Minimally invasive surfactant therapy with a gastric tube is as effective as the intubation, surfactant, and extubation technique in preterm babies"],"prefix":"10.1111","volume":"103","author":[{"given":"Marta","family":"Aguar","sequence":"first","affiliation":[{"name":"Division of Neonatology University &amp; Polytechnic Hospital La Fe Valencia Spain"},{"name":"Neonatal Research Group Health Research Institute La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Cernada","sequence":"additional","affiliation":[{"name":"Neonatal Research Group Health Research Institute La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Brugada","sequence":"additional","affiliation":[{"name":"Division of Neonatology University &amp; Polytechnic Hospital La Fe Valencia Spain"},{"name":"Neonatal Research Group Health Research Institute La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Division of Neonatology University &amp; Polytechnic Hospital La Fe Valencia Spain"},{"name":"Neonatal Research Group Health Research Institute La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Division of Neonatology University &amp; Polytechnic Hospital La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ximo","family":"Vento","sequence":"additional","affiliation":[{"name":"Division of Neonatology University &amp; Polytechnic Hospital La Fe Valencia Spain"},{"name":"Neonatal Research Group Health Research Institute La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199303253281208"},{"key":"e_1_2_8_3_1","first-page":"CD001149","article-title":"Synthetic surfactant for respiratory distress syndrome in preterm infants","volume":"3","author":"Soll R","year":"1998","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2002.0129"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000178770"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410203311603"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2001.00624.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0b013e31824c1583"},{"key":"e_1_2_8_9_1","first-page":"S455","article-title":"Airway complications in neonates who received mechanical ventilation","volume":"85","author":"Kolatat T","year":"2002","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1290-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3848"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2131"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02126.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60986-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0394"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.5.961"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301314"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0603"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00617.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.9902016"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072788"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911783"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12611","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:12:02Z","timestamp":1696500722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,15]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/apa.12611"],"URL":"https:\/\/doi.org\/10.1111\/apa.12611","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,15]]},"assertion":[{"value":"2013-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}