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We aimed to determine cut\u2010off levels for <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> for 10 common inhalant allergens and to study the relationship between <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>, total IgE and fractional exhaled nitric oxide (FE<jats:sub>NO<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 243 schoolchildren, including 164 with allergic rhinoconjunctivitis. Parental interviews, skin prick tests, <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>, total IgE, FE<jats:sub>NO<\/jats:sub> measurements, spirometry and exercise tests were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cut\u2010off values with the best combined sensitivity and specificity were above the detection limit of the assay for seven of the ten allergens (0.23\u20131.1\u00a0kU\/L). The overall accuracy of the IMMULITE<jats:sup>\u00ae<\/jats:sup> in detecting allergic rhinoconjunctivitis was good. <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> was superior to total IgE and FE<jats:sub>NO<\/jats:sub> in predicting allergic rhinoconjunctivitis to timothy, birch, mugwort, cat, dog and house dust mite. FE<jats:sub>NO<\/jats:sub> was elevated in children with allergic rhinoconjunctivitis, irrespective of asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cut\u2010off values for <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> were dependent on the allergic phenotype and were above the <jats:styled-content style=\"fixed-case\">IMMULITE<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> detection limit for seven of ten inhalant allergens. Consequently, using the detection limit for <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> as the decision point would result in over\u2010diagnosing allergic rhinoconjunctivitis. When measuring elevated FE<jats:sub>NO<\/jats:sub> in children, allergic rhinoconjunctivitis should be suspected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12631","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T05:42:39Z","timestamp":1394775759000},"page":"759-765","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Establishing <scp>IMMULITE<\/scp><sup>\u00ae<\/sup> 2000 cut\u2010off values for serum allergen\u2010specific immunoglobulin and exploring their relationship to exhaled nitric oxide"],"prefix":"10.1111","volume":"103","author":[{"given":"Bj\u00f8rg","family":"Evjenth","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatrics Obstetrics and Women's Health Nordland Hospital Bod\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonje 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