{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:15:00Z","timestamp":1761401700029},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Hypoglycaemia is a significant problem in high\u2010risk neonates and predominant parieto\u2010occipital lobe involvement has been observed after severe hypoglycaemic insult. We explored the use of flash visual evoked potentials (<jats:styled-content style=\"fixed-case\">FVEP<\/jats:styled-content>) in detecting parieto\u2010occipital lobe involvement after significant hypoglycaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Full\u2010term neonates (n\u00a0=\u00a015) who underwent <jats:styled-content style=\"fixed-case\">FVEP<\/jats:styled-content> from January 2008 to May 2013 were compared with infants (n\u00a0=\u00a011) without hypoglycaemia or parietal\u2010occipital lobe injury. Significant hypoglycaemia was defined as being symptomatic or needing steroids, glucagon or a glucose infusion rate of \u226512\u00a0mg\/kg\/min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The hypoglycaemia group exhibited delayed latency of the first positive waveform on <jats:styled-content style=\"fixed-case\">FVEP<\/jats:styled-content>. The initial detected time for hypoglycaemia was later in the eight subjects with seizures (median 51\u2010h\u2010old) than those without (median 22\u2010h\u2010old) (P\u00a0=\u00a00.003). Magnetic resonance imaging showed that 80% of the hypoglycaemia group exhibited occipital\u2010lobe injuries, and they were more likely to exhibit abnormal <jats:styled-content style=\"fixed-case\">FVEP<\/jats:styled-content> morphology (P\u00a0=\u00a00.007) than the controls. <jats:styled-content style=\"fixed-case\">FVEP<\/jats:styled-content> exhibited 100% sensitivity, but only 25% specificity, for detecting injuries to the parieto\u2010occipital lobes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Flash visual evoked potential (<jats:styled-content style=\"fixed-case\">FVEP<\/jats:styled-content>) was sensitive, but not sufficiently specific, in identifying parieto\u2010occipital lobe injuries among term neonates exposed to significant hypoglycaemia. Larger studies exploring the potential role of <jats:styled-content style=\"fixed-case\">FVEP<\/jats:styled-content> in neonatal hypoglycaemia are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12673","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T07:24:02Z","timestamp":1399361042000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Flash visual evoked potentials are not specific enough to identify parieto\u2010occipital lobe involvement in term neonates after significant hypoglycaemia"],"prefix":"10.1111","volume":"103","author":[{"given":"Liyuan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiufang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.30.4.295"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2822"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992280504400906"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-009-9195-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.132985"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.33549\/physiolres.930594","article-title":"Kreml\u00e1cek J. Influence of physiological changes of glycaemia on VEPs and visual ERPs","volume":"54","author":"Kubov\u00e1 Z","year":"2005","journal-title":"Physiol Res"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198007000-00007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(73)90038-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(83)90002-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1972.tb02615.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-005-0818-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.09.025"},{"key":"e_1_2_6_16_1","first-page":"5","article-title":"A prospective controlled study of neonatal hypoglycaemia","volume":"54","author":"Pildes RS","year":"1974","journal-title":"Pediatrics"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12673","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:07:57Z","timestamp":1695488877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,19]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/apa.12673"],"URL":"https:\/\/doi.org\/10.1111\/apa.12673","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,19]]},"assertion":[{"value":"2013-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}