{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:52:44Z","timestamp":1785433964993,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Department of Science, Technology and Innovation COLCIENCIAS in Colombia and Centro M\u00ef\u00bf\u00bddico Imbanaco, Cali, Colombia"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Providing consistent levels of oxygen saturation (SpO<jats:sub>2<\/jats:sub>) for infants in neonatal intensive care units is not easy. This study explored how effectively the Auto\u2010Mixer<jats:sup>\u00ae<\/jats:sup>algorithm automatically adjusted fraction of inspired oxygen (FiO<jats:sub>2<\/jats:sub>) levels to maintain SpO<jats:sub>2<\/jats:sub>within an intended range in extremely low birth weight infants receiving supplemental oxygen without mechanical ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty extremely low birth weight infants were randomly assigned to the Auto\u2010Mixer<jats:sup>\u00ae<\/jats:sup>group or the manual intervention group and studied for 12\u00a0h. The SpO<jats:sub>2<\/jats:sub>target was 85\u201393%, and the outcomes were the percentage of time SpO<jats:sub>2<\/jats:sub>was within target, SpO<jats:sub>2<\/jats:sub>variability, SpO<jats:sub>2<\/jats:sub>&gt;95%, oxygen received and manual interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of time within intended SpO<jats:sub>2<\/jats:sub>was 58\u00a0\u00b1\u00a04% in the Auto\u2010Mixer<jats:sup>\u00ae<\/jats:sup>group and 33.7\u00a0\u00b1\u00a04.7% in the manual group, SpO<jats:sub>2<\/jats:sub>&gt;95% was 26.5% vs 54.8%, average SpO<jats:sub>2<\/jats:sub>and FiO<jats:sub>2<\/jats:sub>were 89.8% vs 92.2% and 37% vs 44.1%, and manual interventions were 0 vs 80 (p\u00a0&lt;\u00a00.05). Brief periods of SpO<jats:sub>2<\/jats:sub>\u00a0&lt;\u00a085% occurred more frequently in the Auto\u2010Mixer<jats:sup>\u00ae<\/jats:sup>group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Auto\u2010Mixer<jats:sup>\u00ae<\/jats:sup>effectively increased the percentage of time that SpO<jats:sub>2<\/jats:sub>was within the intended target range and decreased the time with high SpO<jats:sub>2<\/jats:sub>in spontaneously breathing extremely low birth weight infants receiving supplemental oxygen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12684","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T11:52:43Z","timestamp":1399809163000},"page":"928-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["A randomised controlled trial of an automated oxygen delivery algorithm for preterm neonates receiving supplemental oxygen without mechanical 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