{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:13:06Z","timestamp":1780539186682,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to provide an overview of foetal\/neonatal alloimmune neutropenia (<jats:styled-content style=\"fixed-case\">FNAIN<\/jats:styled-content>), together with advice on the clinical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Neutrophil serology in the Netherlands is centralised at Sanquin Diagnostic Services. We examined <jats:styled-content style=\"fixed-case\">FNAIN<\/jats:styled-content> cases between January 1, 1991, and July 1, 2013, to determine the number of cases diagnosed, the relationship with human neutrophil antigen (<jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>) antibody, the clinical presentation and therapeutic interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 35 <jats:styled-content style=\"fixed-case\">FNAIN<\/jats:styled-content> cases. The detected <jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content> antibodies were as follows: anti\u2010<jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20101a (n\u00a0=\u00a07), anti\u2010<jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20101b (n\u00a0=\u00a012), anti\u2010<jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20101c (n\u00a0=\u00a02), anti\u2010<jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20102 (n\u00a0=\u00a08), anti\u2010<jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20103a (n\u00a0=\u00a01), anti\u2010<jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20105a (n\u00a0=\u00a01) and anti\u2010Fc<jats:italic>\u03b3<\/jats:italic><jats:styled-content style=\"fixed-case\">RIII<\/jats:styled-content>b (n\u00a0=\u00a04). No infections were diagnosed in 14 neonates, and the other 21 neonates suffered from omphalitis (n\u00a0=\u00a06), urinary tract infection (n\u00a0=\u00a01), candida mucositis (n\u00a0=\u00a01), fever of unknown origin (n\u00a0=\u00a06) and sepsis (n\u00a0=\u00a07, 20%). Parity, gestational age, birthweight, neutrophil counts and antibody specificity were not significantly different for cases with, and without, infections. All the infected children were treated with antibiotics. No children died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than half (21) of the 35 cases of <jats:styled-content style=\"fixed-case\">FNAIN<\/jats:styled-content> presented with infections and most implicated were <jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20101a, <jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20101b and <jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content>\u20102. Treatment with antibiotics seemed adequate. A neonatal neutropenia workflow model for use in neonatal intensive care units is presented.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12741","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T08:59:11Z","timestamp":1404982751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Management and outcome of 35 cases with foetal\/neonatal alloimmune neutropenia"],"prefix":"10.1111","volume":"103","author":[{"given":"Rita","family":"van den Tooren\u2010de Groot","sequence":"first","affiliation":[{"name":"Department of Pediatrics Bronovo hospital Den Haag The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ottink","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medisch Spectrum Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elly","family":"Huiskes","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"van Rossum","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Bronovo hospital Den Haag The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibian","family":"van der Voorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Bronovo hospital Den Haag The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennichjen","family":"Slomp","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry MEDLON Enschede The Netherlands"},{"name":"Department of Clinical Chemistry Medisch Spectrum Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masja","family":"de Haas","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leendert","family":"Porcelijn","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1182\/blood.V15.2.236.236","article-title":"Neonatal neutropenia due to maternal immunization","volume":"15","author":"Lalezari 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