{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:16:42Z","timestamp":1780553802517,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study compared the efficacy of intravenous magnesium sulphate, terbutaline and aminophylline for children with acute, severe asthma poorly responsive to standard initial treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 100 children, aged one to 12\u00a0years, who had failed to respond to initial standard treatment for acute, severe asthma, in this randomised controlled trial. They received either intravenous magnesium sulphate, terbutaline or aminophylline. Responses were monitored using a modified Clinical Asthma Severity (<jats:styled-content style=\"fixed-case\">CAS<\/jats:styled-content>) score. The primary outcome was treatment success, defined as a reduction in the <jats:styled-content style=\"fixed-case\">CAS<\/jats:styled-content> of four points or more 1\u00a0h after starting the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The magnesium sulphate group had higher treatment success (33\/34, 97%) than the terbutaline and aminophylline groups (both 23\/33, 70%) (p\u00a0=\u00a00.006) and faster resolution of retractions, wheeze and dyspnoea (p\u00a0&lt;\u00a00.001). No adverse events occurred among patients receiving magnesium sulphate, but two patients receiving terbutaline had hypokalemia and nine patients receiving aminophylline had nausea and, or, vomiting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adding a single dose of Intravenous magnesium sulphate to inhaled beta2\u2010agonists and corticosteroids was more effective, and safer, than using terbutaline or aminophylline when treating a child with acute severe asthma poorly responsive to initial treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12780","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T12:44:24Z","timestamp":1409143464000},"page":"1301-1306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Randomised comparison of intravenous magnesium sulphate, terbutaline and aminophylline for children with acute severe asthma"],"prefix":"10.1111","volume":"103","author":[{"given":"Sunit","family":"Singhi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhanshu","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00526.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120018788"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/49.4.207"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2008.10.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-011-0524-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465811398721"},{"key":"e_1_2_9_9_1","unstructured":"National Asthma Education and Prevention Program. 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