{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:36:48Z","timestamp":1778611008233,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study determined the influence of prematurity on the manifestation and treatment of neonatal abstinence syndrome (<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a medical record review of Australian infants exposed to opiates in 2004 and 2007. Finnegan scores were obtained for 215 of 361 (59%) preterm infants under 37\u2010week gestation and 694 of 1178 (59%) term infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean and standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) gestational ages were 34 (3) and 38 (3) weeks for preterm and term infants, respectively. Maternal daily methadone doses were similar for the preterm and term infants with a mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) of 79\u00a0mg (39) versus 72\u00a0mg (38) (p\u00a0=\u00a00.06). Maximum Finnegan scores were significantly lower in preterm infants (10 versus 11, p\u00a0=\u00a00.01), scores were positively correlated with gestation and fewer preterm infants were medicated for <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> (40% versus 48% p\u00a0=\u00a00.05). Maximum median daily and interquartile range morphine doses were lower for preterm than term infants (0.5\u00a0mg\/kg\/day (0.3\u20130.6) versus 0.5\u00a0mg\/kg\/day (0.4\u20130.7), p\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preterm infants were just as likely to be monitored for withdrawal as term infants, but their Finnegan scores were lower and fewer preterm infants were treated for <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>. Whether this indicates decreased <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> severity or physiological immaturity is uncertain. Other means of evaluating <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> in preterm infants are warranted, especially long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12910","type":"journal-article","created":{"date-parts":[[2015,1,25]],"date-time":"2015-01-25T10:41:28Z","timestamp":1422182488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Prematurity reduces the severity and need for treatment of neonatal abstinence syndrome"],"prefix":"10.1111","volume":"104","author":[{"given":"Radhika","family":"Ruwanpathirana","sequence":"first","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales Kensington NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E.","family":"Abdel\u2010Latif","sequence":"additional","affiliation":[{"name":"Department of Neonatology The Canberra Hospital and Australian National University Garran ACT Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Burns","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Kensington NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales Kensington NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Newborn Care Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Lui","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales Kensington NSW Australia"},{"name":"Department of Newborn Care Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Lee","family":"Oei","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales Kensington NSW Australia"},{"name":"Department of Newborn Care Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"19","article-title":"Assessment and treatment of abstinence in infant of drug\u2010dependent mothers","volume":"12","author":"Finnegan LP","year":"1975","journal-title":"Int J Clin Pharmacol Biopharm"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.157305"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01031.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82214-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2007.063"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0b013e318241bd73"},{"key":"e_1_2_7_8_1","volume-title":"The international statistical classification of diseases, and related health problems, 10th revision, Australian modification (ICD\u201010\u2010AM)","author":"National Centre for Classification in Health","year":"2002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000228018.48783.34"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2010.01146.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2007.09.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1547-5069.2003.00345.x"},{"key":"e_1_2_7_13_1","unstructured":"New South Wales Health.Neonatal abstinence syndrome guidelines. Available at:www.health.nsw.gov.au\/policies\/pd\/2005\/policies\/pd\/2005\/pd2005_494.html. (accessed on April 24 2014)."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.03.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq035"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30070-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/002204260903900110"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.08.047"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1561"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0370-4475(83)80028-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.025270"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1542\/peds.97.6.851","article-title":"Cocaine\u2010exposed preterm neonates show behavioral and hormonal differences","volume":"97","author":"Scafidi FA","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1947.62890100006006c"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2001.tb00140.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.3951"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.12910","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.12910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:09:54Z","timestamp":1696471794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.12910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/apa.12910"],"URL":"https:\/\/doi.org\/10.1111\/apa.12910","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]},"assertion":[{"value":"2014-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}