{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T10:21:43Z","timestamp":1764411703699},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated whether providing extremely low birthweight (<jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content>) infants with a large amount of hydrocortisone had a serious suppressive effect on the later function of the hypothalamus\u2013pituitary\u2013adrenal (<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>) axis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the function of the <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis in 58 <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants receiving 9.0\u00a0\u00b1\u00a07.2\u00a0mg\/kg of intravenous and 68.1\u00a0\u00b1\u00a034.1\u00a0mg\/kg of oral hydrocortisone using a human corticotropin\u2010releasing hormone stimulation test. The mean age at investigation was 12.0\u00a0\u00b1\u00a05.2\u00a0months. The response was judged to be normal when the maximum to minimum ratio of the plasma adrenocorticotropic hormone (<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>) concentration was &gt;2, the peak value of the serum cortisol concentration was &gt;552\u00a0nmol\/L, or the increment was &gt;193\u00a0nmol\/L than baseline concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 58 infants studied, 51 (88%) displayed a normal response to both the <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> and cortisol secretion and seven infants (12%) who were judged to be poor responders exhibited a peak cortisol value of &gt;386\u00a0nmol\/L without any episode of adrenal insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Providing <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants with a daily low dose of long\u2010term hydrocortisone therapy should not lead to a serious suppressive effect on the later function of the <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis, regardless of the administration method.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12926","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T15:01:49Z","timestamp":1421766109000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal hydrocortisone therapy does not have a serious suppressive effect on the later function of the hypothalamus\u2013pituitary\u2013adrenal axis"],"prefix":"10.1111","volume":"104","author":[{"given":"Toshimitsu","family":"Takayanagi","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Saga National Hospital Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department 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