{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:40:46Z","timestamp":1762033246847},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Toll\u2010like receptor (TLR<\/jats:styled-content>) 1, 2, 6 and 10, the TLR<\/jats:styled-content>2 subfamily, are known to be associated with immunity against tuberculosis. We evaluated whether polymorphisms in genes encoding TLR<\/jats:styled-content>1, TLR<\/jats:styled-content>2 and TLR<\/jats:styled-content>6 were associated with osteitis in infants who received the Bacillus Calmette\u2010Gu\u00e9rin<\/jats:italic> (BCG<\/jats:styled-content><\/jats:italic>) vaccination soon after birth.<\/jats:p><\/jats:sec>Methods<\/jats:title>Blood samples from 132 adults aged 21\u201349 who had BCG<\/jats:styled-content><\/jats:italic> osteitis in early childhood were analysed in a controlled study for TLR<\/jats:styled-content>1<\/jats:italic> T1805G (rs5743618), TLR<\/jats:styled-content>2<\/jats:italic> G2258A (rs5743708) and TLR<\/jats:styled-content>6<\/jats:italic> C745T (rs5743810) gene single nucleotide polymorphisms.<\/jats:p><\/jats:sec>Results<\/jats:title>The frequencies of the variant genotypes differed between the cases and controls: 11.4% versus 5.7% for TLR<\/jats:styled-content>2<\/jats:italic> G2258A (p\u00a0=\u00a00.033) and 77.3% versus 61.6% for TLR<\/jats:styled-content>6<\/jats:italic> C745T (p\u00a0=\u00a00.001). The TLR<\/jats:styled-content>2<\/jats:italic> and TLR<\/jats:styled-content>6<\/jats:italic> variant genotypes were associated with a higher risk of BCG<\/jats:styled-content><\/jats:italic> osteitis, with adjusted odds ratios (aOR<\/jats:styled-content>) of 2.154 (95%CI<\/jats:styled-content> 1.026\u20134.521) and 1.907 (95%CI<\/jats:styled-content> 1.183\u20133.075), respectively. The frequency of the TLR<\/jats:styled-content>1<\/jats:italic> T1805G variant genotype was 19.7% in the cases and 33.6% in the controls (p\u00a0=\u00a00.003). The TLR<\/jats:styled-content>1<\/jats:italic> variant genotype was associated with a lower risk of BCG<\/jats:styled-content><\/jats:italic> osteitis (aOR<\/jats:styled-content> 0.554, 95%CI<\/jats:styled-content> 0.336\u20130.911).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Gene polymorphisms that regulate the function of the TLR<\/jats:styled-content>2 subfamily play a role in the development of BCG<\/jats:styled-content><\/jats:italic> osteitis in vaccinated infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12927","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T17:13:08Z","timestamp":1421773988000},"page":"485-490","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Toll\u2010like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette\u2010Gu\u00e9rin<\/i> osteitis following newborn vaccination"],"prefix":"10.1111","volume":"104","author":[{"given":"Laura","family":"P\u00f6yh\u00f6nen","sequence":"first","affiliation":[{"name":"Center for Child Health Research University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"Nuolivirta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sein\u00e4joki Central Hospital Sein\u00e4joki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juho","family":"Vuononvirta","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Surveillance and Control National Institute for Health and Welfare Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"School of Health Sciences University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Mertsola","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Turku and University Hospital Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiushui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Surveillance and Control National Institute for Health and Welfare Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[{"name":"Center for Child Health Research University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.96.1.29","article-title":"The efficacy of Bacillus Calmette\u2010Gu\u00e9rin vaccination of newborns and infants in the prevention of tuberculosis. 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