{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:24:15Z","timestamp":1758925455025,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Frimurare-Barnhusdirektionen"},{"name":"Swedish Government Grants for Medical Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine whether the concentration of cytokines in the gastric fluid at birth was associated with chorioamnionitis or funisitis and with the white blood cell counts of very premature newborns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved gastric fluid from 27 preterm infants with a gestational age of &lt;29\u00a0weeks within 1\u00a0h of birth and used enzyme\u2010linked immunosorbent assay to measure the concentrations of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101beta, epithelial cell\u2010derived neutrophil\u2010activating peptide (<jats:styled-content style=\"fixed-case\">ENA<\/jats:styled-content>)\u201078, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 and growth\u2010related oncogene (Gro)\u2010alpha. The presence of histologic chorioamnionitis or funisitis in the placentas and the highest white blood cell count of the infants during the first week of life were compared to the cytokine concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gastric fluid concentrations of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101beta, <jats:styled-content style=\"fixed-case\">ENA<\/jats:styled-content>\u201078, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 and Gro\u2010alpha were strongly associated with chorioamnionitis and funisitis. In addition, chorioamnionitis and funisitis and gastric aspirate cytokine levels were associated with the highest white blood cell counts of the infants during the first week of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that levels of inflammatory cytokines in the gastric fluid of premature infants at birth can be used to assess the exposure of the infants to antenatal inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12947","type":"journal-article","created":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T07:18:59Z","timestamp":1422775139000},"page":"575-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gastric fluid cytokines are associated with chorioamnionitis and white blood cell counts in preterm infants"],"prefix":"10.1111","volume":"104","author":[{"given":"K J K","family":"Bry","sequence":"first","affiliation":[{"name":"Department of 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