{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:23:46Z","timestamp":1777584226597,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Timely detection of hypoxic\u2013ischaemic encephalopathy (HIE<\/jats:styled-content>) is crucial for selecting neonates who are likely to benefit from neuroprotective therapy. This study evaluated the efficacy of salivary lactate dehydrogenase (LDH<\/jats:styled-content>) in the early diagnosis of HIE<\/jats:styled-content> among neonates with perinatal asphyxia.<\/jats:p><\/jats:sec>Methods<\/jats:title>We prospectively enrolled 30 neonates who needed resuscitation at birth or had a history of delayed cry into the HIE<\/jats:styled-content> group if they developed HIE<\/jats:styled-content> within 12\u00a0h of birth. The control group comprised 30 neonates who had no evidence of HIE<\/jats:styled-content>, but had intrapartum foetal distress or needed resuscitation at birth. LDH<\/jats:styled-content> was measured using saliva samples collected within 12\u00a0h of birth.<\/jats:p><\/jats:sec>Results<\/jats:title>Salivary LDH<\/jats:styled-content> was significantly higher in the HIE<\/jats:styled-content> group, with a median of 2578 and an interquartile range (IQR<\/jats:styled-content>) of 1379\u20133408 international units per litre (IU<\/jats:styled-content>\/L), than in the\u00a0control group (median 558.5, IQR<\/jats:styled-content>: 348\u2013924 IU<\/jats:styled-content>\/L, p\u00a0<\u00a00.001). The test demonstrated\u00a0excellent discriminating ability: the area under the curve was 0.92 and the levels of 893 IU<\/jats:styled-content>\/L showed a\u00a0sensitivity of 90% and a specificity of 73.3%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Measuring salivary LDH<\/jats:styled-content> among neonates with birth asphyxia provided an early and accurate diagnosis of HIE<\/jats:styled-content> and could be used as a triage tool.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12964","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T13:19:06Z","timestamp":1423142346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Salivary lactate dehydrogenase levels can provide early diagnosis of hypoxic\u2013ischaemic encephalopathy in neonates with birth 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