{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:08:25Z","timestamp":1787681305701,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T00:00:00Z","timestamp":1426032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Accurate calculations of testicular volume standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) scores are not currently available. We constructed <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content>\u2010smoothed age\u2010reference charts for testicular volume in healthy boys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content> method was used to calculate reference data, based on testicular volumes from ultrasonography and Prader orchidometer of 769 healthy Dutch boys aged 6\u00a0months to 19\u00a0years. We also explored the association between testicular growth and pubic hair development, and data were compared to orchidometric testicular volumes from the 1997 Dutch nationwide growth study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content>\u2010smoothed reference charts showed that no revision of the definition of normal onset of male puberty \u2013 from nine to 14\u00a0years of age \u2013 was warranted. In healthy boys, the pubic hair stage <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> scores corresponded with testicular volume <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> scores (r<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.394). However, testes were relatively small for pubic hair stage in Klinefelter's syndrome and relatively large in immunoglobulin superfamily member 1 deficiency syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The age\u2010corrected <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> scores for testicular volume will aid in the diagnosis and follow\u2010up of abnormalities in the timing and progression of male puberty and in research evaluations. The <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> scores can be compared with pubic hair <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> scores to identify discrepancies between cell functions that result in relative microorchidism or macroorchidism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12972","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T10:07:07Z","timestamp":1423476427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["New reference charts for testicular volume in Dutch children and adolescents allow the calculation of standard deviation scores"],"prefix":"10.1111","volume":"104","author":[{"given":"Sjoerd D.","family":"Joustra","sequence":"first","affiliation":[{"name":"Department of Pediatrics Leiden University Medical Center Leiden Netherlands"},{"name":"Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn M.","family":"van der Plas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical Centre Alkmaar Alkmaar Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joery","family":"Goede","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical Centre Alkmaar Alkmaar Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Oostdijk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Leiden University Medical Center Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette A.","family":"Delemarre\u2010van de Waal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Leiden University Medical Center Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried 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