{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:58:21Z","timestamp":1768834701971,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to compare visual function and ocular characteristics in children with cochlear implants, due to severe hearing impairment caused by the congenital cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) infection, with control children fitted with cochlear implants due to connexin 26 mutations (Cx26), a genetic cause of hearing impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out ophthalmological assessments, including visual acuity, ocular alignment, Ocular Motor Score, biomicroscopy and fundus photography, on 26 children with congenital <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> (median age 8.3\u00a0years, range 1.4\u201316.7) and 13 Cx26 controls (median age 5.6\u00a0years, range 1.7\u201312.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found unilateral chorioretinal macular scars that reduced best\u2010corrected visual acuity \u22640.3 in five (19%) of the children with congenital <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>, but in none of the children with Cx26 (p\u00a0=\u00a00.15). Ocular motility problems were more common among children with congenital <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>, but the difference was not significant (p\u00a0=\u00a00.20). The vestibulo\u2010ocular reflex was more frequently pathological in children with congenital <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> (p\u00a0=\u00a00.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ocular complications with central chorioretinal scars and ocular motility disturbances were common in children treated with cochlear implants due to severe hearing impairment caused by the congenital <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection. Ophthalmological assessments are advisable in such children for early identification, intervention and follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.12988","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T10:47:21Z","timestamp":1425034041000},"page":"693-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chorioretinal scars and visual deprivation are common in children with cochlear implants after congenital cytomegalovirus infection"],"prefix":"10.1111","volume":"104","author":[{"given":"Kristina","family":"Te\u00e4r Fahnehjelm","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"},{"name":"Department of Paediatric Ophthalmology and Strabismus St. Erik Eye Hospital Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"},{"name":"Department of Paediatric Ophthalmology and Strabismus St. Erik Eye Hospital Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Fahnehjelm","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Lewensohn\u2010Fuchs","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet Huddinge Sweden"},{"name":"Department of Clinical Microbiology Karolinska University Hospital Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Karltorp","sequence":"additional","affiliation":[{"name":"Department of Clintec Karolinska Institutet Stockholm Sweden"},{"name":"Department of Otorhinolaryngology Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.409"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31822d9640"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22181"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365549950163969"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.544"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199202000-00007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70248-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2005.09.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1748054"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12745"},{"key":"e_1_2_9_13_1","first-page":"273","article-title":"Ocular abnormalities in congenital cytomegalovirus infection","volume":"67","author":"Anderson KS","year":"1996","journal-title":"J Am Optom Assoc"},{"key":"e_1_2_9_14_1","first-page":"465","article-title":"Aplasia ed ipoplasia del nervo ottico. 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