{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:55:19Z","timestamp":1784559319058,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","award":["12610001059055"],"award-info":[{"award-number":["12610001059055"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The starting fraction of inspired oxygen for preterm resuscitation is a matter of debate, and the use of room air in full\u2010term asphyxiated infants reduces oxidative stress. This study compared oxidative stress in preterm infants randomised for resuscitation with either 100% oxygen or room air titrated to internationally recommended levels of preductal oxygen saturations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood was collected at birth, two and 12\u00a0hours of age from 119 infants &lt;32\u00a0weeks of gestation randomised to resuscitation with either 100% oxygen (n\u00a0=\u00a060) or room air (n\u00a0=\u00a059). Oxidative stress markers, including advanced oxidative protein products (<jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content>) and isoprostanes (IsoP), were measured with high\u2010performance liquid chromatography and mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher levels of <jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content> were found at 12\u00a0hours in the 100% oxygen group (p\u00a0&lt;\u00a00.05). Increases between two\u2010 and 12\u2010hour <jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content> (p\u00a0=\u00a00.004) and IsoP (p\u00a0=\u00a00.032) concentrations were significantly higher in the 100% oxygen group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Initial resuscitation with room air versus 100% oxygen was associated with lower protein oxidation at 12\u00a0hour and a lower magnitude of increase in <jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content> and IsoP levels between two and 12\u00a0hours of life. Correlations with clinical outcomes will be vital to optimise the use of oxygen in preterm resuscitation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13039","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T09:25:36Z","timestamp":1431509136000},"page":"759-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Resuscitating preterm infants with 100% oxygen is associated with higher oxidative stress than room air"],"prefix":"10.1111","volume":"104","author":[{"given":"ML","family":"Tataranno","sequence":"first","affiliation":[{"name":"Department of Molecular and Developmental Medicine University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JL","family":"Oei","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney NSW Australia"},{"name":"Department of Newborn Care The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Perrone","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IM","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Paediatrics University of Wollongong Wollongong NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JP","family":"Smyth","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney NSW Australia"},{"name":"Department of Newborn Care The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Lui","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney NSW Australia"},{"name":"Department of Newborn Care The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WO","family":"Tarnow\u2010Mordi","sequence":"additional","affiliation":[{"name":"Australia Westmead International Network for Neonatal Education and Research The University of Sydney Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Longini","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Proietti","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Negro","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OD","family":"Saugstad","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research Oslo University Hospital University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Buonocore","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.04.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151761"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3130"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0434"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(01)00209-2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-011-9589-0"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334226"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2012.01.005"},{"key":"e_1_2_11_10_1","unstructured":"The TO2RPIDO study. 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