{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:26:43Z","timestamp":1772069203364,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to compare the incidence of bronchopulmonary dysplasia (<jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>) in symptomatic ureaplasma\u2010positive treated preterm infants and asymptomatic preterm infants not tested or treated for ureaplasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective matched cohort study was conducted in a tertiary, neonatal unit between January 2007 and December 2012. Infants \u226429 completed weeks with signs and symptoms suggesting ureaplasma pneumonia who received macrolides comprised the study group. Infants \u226429\u00a0weeks without signs and symptoms not tested or treated with macrolides were the controls. Infants were mandatorily matched for gestational age\u00a0\u00b1\u00a0one week or birthweight\u00a0\u00b1\u00a0100 grams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 31 infants in the study group and 62 in the control group. The baseline demographic data of both groups were similar on the whole. The incidence of moderate and severe <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>, defined by oxygen dependency or the need for continuous positive airway pressure at 36\u00a0weeks of postconceptual age, was 45.2% in the study group and 40.3% in the controls (p\u00a0=\u00a00.65). There was no significant difference in morbidities or mortality between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A selective approach of treating symptomatic ureaplasma\u2010positive preterm infants with macrolides did not affect the incidence of moderate and severe <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13098","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T11:37:39Z","timestamp":1435145859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Macrolides do not affect the incidence of moderate and severe bronchopulmonary dysplasia in symptomatic ureaplasma\u2010positive infants"],"prefix":"10.1111","volume":"104","author":[{"given":"Aravanan","family":"Anbu Chakkarapani","sequence":"first","affiliation":[{"name":"Division of Neonatology Department of Pediatrics McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bosco","family":"Paes","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandesh","family":"Shivananda","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"90","article-title":"Domiciliary oxygen for infants with chronic lung disease of prematurity","volume":"16","author":"Dunbar H","year":"2000","journal-title":"Care Crit Ill"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.6.1.69"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1183\/09031936.97.10040886","article-title":"Ureaplasma urealyticum colonization, prematurity and bronchopulmonary dysplasia","volume":"10","author":"Waarde WM","year":"1997","journal-title":"Eur Respir J"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.757-789.2005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000224824.73223.e7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819dc2f9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000100757.38675.50"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363493"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.78.1.F10"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21352"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-8-41"},{"key":"e_1_2_11_14_1","first-page":"1070","article-title":"Efficacy of azithromycin for prevention of bronchopulmonary dysplasia (BPD)","volume":"42","author":"Gharehbaghi MM","year":"2012","journal-title":"Turk J Med Sci"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1350"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-45-1-27"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0249"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0045-9380(87)90031-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2749"},{"key":"e_1_2_11_20_1","unstructured":"The Canadian Neonatal Network. 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