{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:58:48Z","timestamp":1760975928696},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The safety of SwabCap alcohol impregnated disinfection caps was questioned in our unit because of malfunctions in luer access valves. We examined whether SwabCaps affected the integrity of two luer access valves and were associated with alcohol injected into the lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our bench test study included seven circuits using SmartSite or <jats:styled-content style=\"fixed-case\">CARESITE<\/jats:styled-content> valves exposed to two environmental temperatures. Passive circuits consisted of a 96\u2010hour contact system using SwabCap without other interventions. Active circuits consisted of nine sham injections during a 24\u2010hour period, with the SwabCap replaced after each injection. The active control circuit used isopropyl alcohol impregnated pads to disinfect valves. Isopropyl alcohol was measured at the extremity of all active circuits by gas chromatography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The visual appearance of all SmartSite valves and 67% of the <jats:styled-content style=\"fixed-case\">CARESITE<\/jats:styled-content> valves was changed by SwabCap use. The mean isopropyl alcohol dosages were 52\u00a0mmol\/L in the SmartSite and 8\u00a0mmol\/L in the <jats:styled-content style=\"fixed-case\">CARESITE<\/jats:styled-content> at room temperature and 73 and 7\u00a0mmol\/L, respectively, at 35\u00b0C. No alcohol was found in the control circuit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The SwabCap altered the valves' appearance and allowed significant amounts of isopropyl alcohol to be injected. It should not be used for neonates without further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13099","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T11:42:58Z","timestamp":1435146178000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Using isopropyl alcohol impregnated disinfection caps in the neonatal intensive care unit can cause isopropyl alcohol toxicity"],"prefix":"10.1111","volume":"104","author":[{"given":"Charlotte","family":"Sauron","sequence":"first","affiliation":[{"name":"Neonatology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"},{"name":"Neonatology H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Jouvet","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care CHU Sainte\u2010Justine Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Pinard","sequence":"additional","affiliation":[{"name":"Quality, Security and Risk Counsel CHU Sainte\u2010Justine Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Goudreault","sequence":"additional","affiliation":[{"name":"Specialized Biochemistry Laboratory CHU Sainte\u2010Justine Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Martin","sequence":"additional","affiliation":[{"name":"Pharmacy Department CHU Sainte\u2010Justine Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastien","family":"Rival","sequence":"additional","affiliation":[{"name":"Specialized Biochemistry Laboratory CHU Sainte\u2010Justine Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Moussa","sequence":"additional","affiliation":[{"name":"Neonatology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/500280"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.05.030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3617"},{"key":"e_1_2_9_5_1","unstructured":"PongA SalgadoC SpezialeM GrimmP AbeC.Reduction of central line associated bloodstream infection (CLABSI) in a neonatal intensive care unit with use of access site disinfection caps. Poster 672. Infectious Disease Society of America Annual Meeting. October 20\u201023 2011; Boston MA USA."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200008000-00005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A488"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03220807"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1968.03140210088026"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc063237"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563659309000415"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199404000-00008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211646"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13099","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:57:52Z","timestamp":1695509872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/apa.13099"],"URL":"https:\/\/doi.org\/10.1111\/apa.13099","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]},"assertion":[{"value":"2015-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}