{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:52:07Z","timestamp":1784033527691,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:00:00Z","timestamp":1439769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2006\u20103858"],"award-info":[{"award-number":["2006\u20103858"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated sepsis as a risk factor for neonatal morbidities and investigated the association between specific pathogens and neonatal morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a nationwide Swedish prospective cohort study, consisting of the 497 extremely premature children, who were born before 27\u00a0weeks of gestation between 2004 and 2007 and survived their first year of life. Neonatal sepsis was evaluated as a risk factor for neonatal morbidity using multiple logistic linear regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 326 (66%) of the infants had at least one sepsis episode and coagulase\u2010negative staphylococci was the most common pathogen. Definite sepsis, with an odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) of 1.6, was associated with severe bronchopulmonary dysplasia, but not clinical sepsis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.1). Definite sepsis was also associated with a prolonged hospital stay (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.6). Sepsis was not significantly associated with a higher risk of retinopathy of prematurity or intraventricular haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Extremely preterm infants face a great risk of acquiring neonatal sepsis, with coagulase\u2010negative staphylococci being the most common pathogen in this population. Definite sepsis seemed to be a risk factor for severe bronchopulmonary dysplasia and prolonged hospital stay, but the associations were weaker than in previous studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13104","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T17:01:38Z","timestamp":1435424498000},"page":"1070-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Sepsis as a risk factor for neonatal morbidity in extremely preterm infants"],"prefix":"10.1111","volume":"104","author":[{"given":"Andreas","family":"Ohlin","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Bj\u00f6rkman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Serenius","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Section\u00a0for Pediatrics Uppsala University Uppsala Sweden"},{"name":"Department of Pediatrics Institute of Clinical Sciences Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schollin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"K\u00e4ll\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Sciences Centre of Reproduction Epidemiology University of Lund Lund 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