{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:30:43Z","timestamp":1760189443163},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T00:00:00Z","timestamp":1443052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001275","name":"Oak Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Coeliac disease is triggered by an interplay of environmental and genetic factors and is one of the most prevalent autoimmune diseases in children, occurring in about 1% of Europeans. Over the last few decades, there has been a growing interest in the role of the perinatal environment in coeliac disease and this review discusses the growing body of literature on coeliac disease and perinatal risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is still only circumstantial evidence that the perinatal environment influences coeliac disease development. Large\u2010scale cohort studies and emerging scientific concepts, such as epigenetics, may help us establish the role of these environmental factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13150","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T13:08:02Z","timestamp":1439212082000},"page":"366-375","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Current evidence on whether perinatal risk factors influence coeliac disease is circumstantial"],"prefix":"10.1111","volume":"105","author":[{"given":"Karl","family":"M\u00e5rild","sequence":"first","affiliation":[{"name":"Division of Epidemiology Norwegian Institute of Public Health Oslo Norway"},{"name":"Department of Medical Epidemiology &amp; Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology &amp; Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Pediatrics \u00d6rebro University Hospital \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketil","family":"St\u00f8rdal","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Norwegian Institute of Public Health Oslo Norway"},{"name":"Department of Pediatrics \u00d8stfold Hospital Trust Fredrikstad Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,24]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-040210-092915"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1953.tb05563.x"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3407"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1408011"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.55"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.505931"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31818c52cc"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.094045"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03502.x"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.059"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.514285"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.32.1.34"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6673.564"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01036.x"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13163"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1200"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00741.x"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10498.x"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.083964"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.998"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222794"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.09.003"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04110.x"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00313"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313977"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1217"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510024034"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01360.x"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/S1542-3565(03)00180-0"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.008"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.57.1.36"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302360"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181709530"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.661760"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12836"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.08.056"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu101"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1752"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2011.598876"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980013003510"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-19"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107673"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3299"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.09.018"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32834cb791"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta18450"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03234.x"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00949.x"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03428.x"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12973"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093551"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1656"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.061"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32834a4cd1"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1213566"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.10.012"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/08830180215017"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200211000-00011"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181d1b11e"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2011.599084"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13150","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:45:12Z","timestamp":1695732312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,24]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/apa.13150"],"URL":"https:\/\/doi.org\/10.1111\/apa.13150","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,24]]},"assertion":[{"value":"2015-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}